Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5955
Title: Molecular mechanisms of drug resistance and its reversal in cancer
Authors: Kartal Yandım, Melis
Adan Gökbulut, Aysun
Baran, Yusuf
Kartal Yandım, Melis
Adan Gökbulut, Aysun
Baran, Yusuf
Izmir Institute of Technology. Molecular Biology and Genetics
Keywords: ABC transporters
Apoptosis
Bioactive sphingolipids
Cancer
Multidrug resistance
Cell cycle alteration
Issue Date: Jul-2016
Publisher: Taylor and Francis Ltd.
Source: Kartal Yandım, M., Adan Gökbulut, A., and Baran, Y. (2016). Molecular mechanisms of drug resistance and its reversal in cancer. Critical Reviews in Biotechnology, 36(4), 716-726. doi:10.3109/07388551.2015.1015957
Abstract: Chemotherapy is the main strategy for the treatment of cancer. However, the main problem limiting the success of chemotherapy is the development of multidrug resistance. The resistance can be intrinsic or acquired. The resistance phenotype is associated with the tumor cells that gain a cross-resistance to a large range of drugs that are structurally and functionally different. Multidrug resistance arises via many unrelated mechanisms, such as overexpression of energy-dependent efflux proteins, decrease in uptake of the agents, increase or alteration in drug targets, modification of cell cycle checkpoints, inactivation of the agents, compartmentalization of the agents, inhibition of apoptosis and aberrant bioactive sphingolipid metabolism. Exact elucidation of resistance mechanisms and molecular and biochemical approaches to overcome multidrug resistance have been a major goal in cancer research. This review comprises the mechanisms guiding multidrug resistance in cancer chemotherapy and also touches on approaches for reversing the resistance.
URI: https://doi.org/10.3109/07388551.2015.1015957
http://hdl.handle.net/11147/5955
ISSN: 0738-8551
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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