Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5944
Title: Utilization of electrospun polystyrene membranes as a preliminary step for rapid diagnosis
Authors: Işık, Tuğba
Horzum, Nesrin
Yıldız, Ümit Hakan
Liedberg, Bo
Demir, Mustafa Muammer
Keywords: Adsorption
Bioseparations
DNA biomarkers
Electrospinning
Biomarkers
Issue Date: Jul-2016
Publisher: John Wiley and Sons Inc.
Source: Isık, T., Horzum, N., Yıldız, Ü. H., Liedberg, B., and Demir, M. M. (2016). Utilization of electrospun polystyrene membranes as a preliminary step for rapid diagnosis. Macromolecular Materials and Engineering, 301(7), 827-835. doi:10.1002/mame.201600127
Abstract: Recent advances in clinical practice drive deoxyribonucleic acid (DNA) as an important class of biomarker. Monitoring the change in their concentration suggests the initiation and/or progression of various disorders. However, low quantity of DNA biomarkers in body fluids requires a delicate isolation methodology that provides efficient separation and easy handling. This study describes a newer-generation separation technology relying on electrospun fibers of sub-micrometer diameter of a commodity polymer for DNA biomarkers in simulative serum. Fibrous polystyrene membranes are prepared by electrospinning and they are subjected to post-modification with Au. The composite membranes may provide a convenient environment for the removal of bovine serum albumin (BSA) from BSA and DNA mixtures. The eluent can be used as an efficient tool for detection of DNA biomarkers associated with diagnosis of numerous life-threatening diseases.
URI: http://doi.org/10.1002/mame.201600127
http://hdl.handle.net/11147/5944
ISSN: 1438-7492
1438-7492
1439-2054
Appears in Collections:Chemistry / Kimya
Materials Science and Engineering / Malzeme Bilimi ve Mühendisliği
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Sürdürülebilir Yeşil Kampüs Koleksiyonu / Sustainable Green Campus Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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