Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5916
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dc.contributor.authorTezcanlı Kaymaz, Burçin-
dc.contributor.authorSelvi Günel, Nur-
dc.contributor.authorCeyhan, Metin-
dc.contributor.authorBozok Çetintaş, Vildan-
dc.contributor.authorÖzel, Buket-
dc.contributor.authorKartal Yandım, Melis-
dc.contributor.authorKıpçak, Sezgi-
dc.contributor.authorAktan, Çağdaş-
dc.contributor.authorAdan Gökbulut, Aysun-
dc.contributor.authorBaran, Yusuf-
dc.contributor.authorKosova Can, Buket-
dc.date.accessioned2017-07-11T08:43:38Z-
dc.date.available2017-07-11T08:43:38Z-
dc.date.issued2015-09-
dc.identifier.citationTezcanlı Kaymaz, B., Selvi Günel, N., Ceyhan, M., Bozok Çetintaş, V., Özel, B., Kartal Yandım, M., Kıpçak, S., Aktan, Ç., Adan Gökbulut, A., Baran, Y., and Kosova Can, B. (2015). Revealing genome-wide mRNA and microRNA expression patterns in leukemic cells highlighted “hsa-miR-2278” as a tumor suppressor for regain of chemotherapeutic imatinib response due to targeting STAT5A. Tumor Biology, 36(10), 7915-7927. doi:10.1007/s13277-015-3509-9en_US
dc.identifier.issn1423-0380-
dc.identifier.issn1010-4283-
dc.identifier.urihttp://doi.org/10.1007/s13277-015-3509-9-
dc.identifier.urihttp://hdl.handle.net/11147/5916-
dc.description.abstractBCR-ABL oncoprotein stimulates cell proliferation and inhibits apoptosis in chronic myeloid leukemia (CML). For cure, imatinib is a widely used tyrosine kinase inhibitor, but developing chemotherapeutic resistance has to be overcome. In this study, we aimed to determine differing genome-wide microRNA (miRNA) and messenger RNA (mRNA) expression profiles in imatinib resistant (K562/IMA-3 μM) and parental cells by targeting STAT5A via small interfering RNA (siRNA) applications. After determining possible therapeutic miRNAs, we aimed to check their effects upon cell viability and proliferation, apoptosis, and find a possible miRNAen_US
dc.description.sponsorshipEge University Research Fund (APAK 2013-TIP/083)en_US
dc.language.isoenen_US
dc.publisherSAGE Publications Inc.en_US
dc.relation.ispartofTumor Biologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosisen_US
dc.subjectImatinib resistanceen_US
dc.subjectsiRNAen_US
dc.subjectSTAT5Aen_US
dc.subjectTranscriptome and miRNome arrayen_US
dc.subjectChronic myeloid leukemiaen_US
dc.subjectMicroRNAsen_US
dc.titleRevealing genome-wide mRNA and microRNA expression patterns in leukemic cells highlighted “hsa-miR-2278” as a tumor suppressor for regain of chemotherapeutic imatinib response due to targeting STAT5Aen_US
dc.typeArticleen_US
dc.authoridTR119193en_US
dc.institutionauthorKartal Yandım, Melis-
dc.institutionauthorAdan Gökbulut, Aysun-
dc.institutionauthorBaran, Yusuf-
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume36en_US
dc.identifier.issue10en_US
dc.identifier.startpage7915en_US
dc.identifier.endpage7927en_US
dc.identifier.wosWOS:000362969900065en_US
dc.identifier.scopus2-s2.0-84944280437en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s13277-015-3509-9-
dc.identifier.pmid25953263en_US
dc.relation.doi10.1007/s13277-015-3509-9en_US
dc.coverage.doi10.1007/s13277-015-3509-9en_US
dc.identifier.wosqualityN/A-
dc.identifier.scopusqualityQ3-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeArticle-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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