Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5879
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dc.contributor.authorZengin, Talip-
dc.contributor.authorEkinci, Burcu-
dc.contributor.authorKüçükköse, Cansu-
dc.contributor.authorYalçın Özuysal, Özden-
dc.date.accessioned2017-07-07T06:56:10Z-
dc.date.available2017-07-07T06:56:10Z-
dc.date.issued2015-07-10-
dc.identifier.citationZengin, T., Ekinci, B., Küçükköse, C., and Yalçın Özuysal, Ö. (2015). IRF6 is involved in the regulation of cell proliferation and transformation in MCF10A cells downstream of notch signaling. PLoS ONE, 10(7). doi:10.1371/journal.pone.0132757en_US
dc.identifier.issn1932-6203-
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0132757-
dc.identifier.urihttp://hdl.handle.net/11147/5879-
dc.description.abstractIRF6, a member of Interferon Regulatory Factors (IRF) family, is involved in orofacial and epidermal development. In breast cancer cell lines ectopic expression of IRF6 reduces cell numbers suggesting a role as negative regulator of cell cycle. IRF6 is a direct target of canonical Notch signaling in keratinocyte differentiation. Notch is involved in luminal cell fate determination and stem cell regulation in the normal breast and is implicated as an oncogene in breast cancer. Notch activation is sufficient to induce proliferation and transformation in non-tumorigenic breast epithelial cell line, MCF10A. ΔNp63, which is downregulated by Notch activation in the breast, regulates IRF6 expression in keratinocytes. In this report, we investigate Notch-IRF6 and ΔNp63-IRF6 interactions in MCF10A and MDA MB 231 cells. We observed that in these cells, IRF6 expression is partially regulated by canonical Notch signaling and ΔNp63 downregulation. Furthermore, we demonstrate that IRF6 abrogation impairs Notch-induced proliferation and transformation in MCF10A cells. Thus, we confirm the previous findings by showing a tissue independent regulation of IRF6 by Notch signaling, and extend them by proposing a context dependent role for IRF6, which acts as a positive regulator of proliferation and transformation in MCF10A cells downstream of Notch signaling.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (110T895); Izmir Institute of Technologyen_US
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.relationinfo:eu-repo/grantAgreement/TUBITAK/TBAG/110T895en_US
dc.relation.ispartofPLoS ONEen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMessenger RNAen_US
dc.subjectNotch receptoren_US
dc.subjectInterferon Regulatory Factors (IRF)en_US
dc.subjectIRF6en_US
dc.subjectCancer cellsen_US
dc.subjectBreast canceren_US
dc.subjectCell transformationen_US
dc.titleIRF6 is involved in the regulation of cell proliferation and transformation in MCF10A cells downstream of notch signalingen_US
dc.typeArticleen_US
dc.authoridTR103812en_US
dc.institutionauthorZengin, Talip-
dc.institutionauthorEkinci, Burcu-
dc.institutionauthorKüçükköse, Cansu-
dc.institutionauthorYalçın Özuysal, Özden-
dc.departmentIzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume10en_US
dc.identifier.issue7en_US
dc.identifier.wosWOS:000358162300174
dc.identifier.scopusSCOPUS:2-s2.0-84941359807
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1371/journal.pone.0132757-
dc.relation.doi10.1371/journal.pone.0132757en_US
dc.coverage.doi10.1371/journal.pone.0132757en_US
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.grantfulltextopen-
item.languageiso639-1en-
item.fulltextWith Fulltext-
crisitem.author.deptDepartment of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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