Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5848
Title: Glycoalkaloid isolation from Solanum linnaeanum berries
Authors: Gürbüz, Nergiz
Karabey, Fatih
Öztürk, Taylan Kurtuluş
Kılınç, Ali
Frary, Anne
Doğanlar, Sami
Keywords: Glycoalkaloids
Nightshade
Solamargine
Solanum linnaeanum
Solasonine
Publisher: EDP Sciences
Source: Gürbüz, N., Karabey, F., Öztürk, T. K., Kılınç, A., Frary, A. and Doğanlar, S. (2015). Glycoalkaloid isolation from Solanum linnaeanum berries. Fruits, 70(6), 371-375. doi:10.1051/fruits/2015037
Abstract: Glycoalkaloids are plant secondary metabolites that can be both harmful and beneficial to human health. They cause gastroenteric symptoms, coma and even death at high concentrations. It is thought that glycoalkaloids are toxic to human health as a result of their effects on the nervous system and destruction of cell membranes. On the other hand, glycoalkaloids can be effective drugs. For example, solasodine is used to treat skin cancer and tomatidine is used in cancer chemotherapy. Solasodine is also used as a precursor of steroidal drugs. The goal of the work was to isolate and separate efficiently these similar compounds. Materials and methods. Glycoalkaloids from Solanum linnaeanum berries were isolated using column chromatography and confirmed via NMR spectroscopy and MS/MS spectrometry. Results and discussion. The chemical structures of glycoalkaloids are nearly identical. For example, solamargine differs from solasonine in having a methyl group instead of a hydroxyl group bound to the sugar residue of the compound. Thus, their molecular weight and polarity are quite similar. In this work, the process yielded 37.1 mg solasonine, 92.3 mg solasonine and solamargine mix and 56.2 mg solamargine from 81.67 g dried S. linnaeanum berries. Conclusion. Solanum linnaeanum berries are a good source of these glycoalkaloids and the developed protocol proved efficient for purification of solasonine and solamargine.
URI: http://doi.org/10.1051/fruits/2015037
http://hdl.handle.net/11147/5848
ISSN: 0248-1294
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Files in This Item:
File Description SizeFormat 
5848.pdfMakale993.29 kBAdobe PDFThumbnail
View/Open
Show full item record



CORE Recommender

SCOPUSTM   
Citations

3
checked on Apr 5, 2024

WEB OF SCIENCETM
Citations

2
checked on Mar 30, 2024

Page view(s)

1,954
checked on Apr 22, 2024

Download(s)

392
checked on Apr 22, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.