Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5848
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dc.contributor.authorGürbüz, Nergiz-
dc.contributor.authorKarabey, Fatih-
dc.contributor.authorÖztürk, Taylan Kurtuluş-
dc.contributor.authorKılınç, Ali-
dc.contributor.authorFrary, Anne-
dc.contributor.authorDoğanlar, Sami-
dc.date.accessioned2017-07-04T11:21:34Z-
dc.date.available2017-07-04T11:21:34Z-
dc.date.issued2015-11-
dc.identifier.citationGürbüz, N., Karabey, F., Öztürk, T. K., Kılınç, A., Frary, A. and Doğanlar, S. (2015). Glycoalkaloid isolation from Solanum linnaeanum berries. Fruits, 70(6), 371-375. doi:10.1051/fruits/2015037en_US
dc.identifier.issn0248-1294-
dc.identifier.urihttp://doi.org/10.1051/fruits/2015037-
dc.identifier.urihttp://hdl.handle.net/11147/5848-
dc.description.abstractGlycoalkaloids are plant secondary metabolites that can be both harmful and beneficial to human health. They cause gastroenteric symptoms, coma and even death at high concentrations. It is thought that glycoalkaloids are toxic to human health as a result of their effects on the nervous system and destruction of cell membranes. On the other hand, glycoalkaloids can be effective drugs. For example, solasodine is used to treat skin cancer and tomatidine is used in cancer chemotherapy. Solasodine is also used as a precursor of steroidal drugs. The goal of the work was to isolate and separate efficiently these similar compounds. Materials and methods. Glycoalkaloids from Solanum linnaeanum berries were isolated using column chromatography and confirmed via NMR spectroscopy and MS/MS spectrometry. Results and discussion. The chemical structures of glycoalkaloids are nearly identical. For example, solamargine differs from solasonine in having a methyl group instead of a hydroxyl group bound to the sugar residue of the compound. Thus, their molecular weight and polarity are quite similar. In this work, the process yielded 37.1 mg solasonine, 92.3 mg solasonine and solamargine mix and 56.2 mg solamargine from 81.67 g dried S. linnaeanum berries. Conclusion. Solanum linnaeanum berries are a good source of these glycoalkaloids and the developed protocol proved efficient for purification of solasonine and solamargine.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (104T224)en_US
dc.language.isoenen_US
dc.publisherEDP Sciencesen_US
dc.relationinfo:eu-repo/grantAgreement/TUBITAK/TBAG/104T224en_US
dc.relation.ispartofFruitsen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGlycoalkaloidsen_US
dc.subjectNightshadeen_US
dc.subjectSolamargineen_US
dc.subjectSolanum linnaeanumen_US
dc.subjectSolasonineen_US
dc.titleGlycoalkaloid isolation from Solanum linnaeanum berriesen_US
dc.typeArticleen_US
dc.authoridTR114553en_US
dc.authoridTR1977en_US
dc.institutionauthorGürbüz, Nergiz-
dc.institutionauthorFrary, Anne-
dc.institutionauthorDoğanlar, Sami-
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume70en_US
dc.identifier.issue6en_US
dc.identifier.startpage371en_US
dc.identifier.endpage375en_US
dc.identifier.wosWOS:000364434400006en_US
dc.identifier.scopus2-s2.0-84946551283en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1051/fruits/2015037-
dc.relation.doi10.1051/fruits/2015037en_US
dc.coverage.doi10.1051/fruits/2015037en_US
dc.identifier.wosqualityQ2-
dc.identifier.scopusqualityQ2-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.openairetypeArticle-
item.cerifentitytypePublications-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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