Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5793
Title: The impact of Onco type DX® recurrence score of paraffin-embedded core biopsy tissues in predicting response to neoadjuvant chemotherapy in women with breast cancer
Authors: Soran, Atilla
Bhargava, Rohit
Johnson, Ronald
Ahrendt, Gretchen
Bonaventura, Marguerite
Diego, Emilia
McAuliffe, Priscilla F.
Serrano, Merida
Menekşe, Ebru
Sezgin, Efe
McGuire, Kandace P.
Sezgin, Efe
Keywords: Breast cancer
Estrogen positive
Tumor volume reduction
21 gene assay
Neoadjuvant therapy
Antineoplastic agent
Issue Date: 2016
Publisher: IOS Press
Source: Soran, A., Bhargava, R., Johnson, R., Ahrendt, G., Bonaventura, M., Diego, E., McAuliffe, P. F., Serrano, M., Menekşe, E., Sezgin, E., and McGuire, K. P. (2016). The impact of Onco type DX® recurrence score of paraffin-embedded core biopsy tissues in predicting response to neoadjuvant chemotherapy in women with breast cancer. Breast Disease, 36(2-3), 65-71. doi:10.3233/BD-150199
Abstract: BACKGROUND: Oncotype DX® test is beneficial in predicting recurrence free survival in estrogen receptor positive (ER+) breast cancer. Ability of the assay to predict response to neoadjuvant chemotherapy (NCT) is less well-studied. OBJECTIVE: We hypothesize a positive association between the Oncotype DX® recurrence score (RS) and the percentage tumor response (%TR) after NCT. METHODS: Pre-therapy RS was measured on core biopsies from 60 patients with ER+, HER2.. invasive breast cancer (IBC) who then received NCT. Pre-therapy tumor size was measured using imaging. %TR, partial response (PR; 50%), pathologic complete response (PCR) and breast conserving surgery (BCS) rates were measured. RESULTS: Median RS was 20 (2 69). Median %TR was 42 (0 97)%. PR was observed in 43% of patients. There was no association between %TR and pre-NCT tumor size, age, Nottingham score or nodal status (p 0:05). No statistically significant association with %TR was seen with RS as a categorical or continuous variable (p = 0:21 and 0.7, respectively). Response to NCT improved as ER (p = 0:02) by RT-PCR decreased. Lower ER expression by IHC correlated with response (p = 0:03). CONCLUSIONS: In patients with ER+ IBC receiving NCT, RS did not predict response to NCT using %TR. The benefit of the assay prior to NCT requires further study.
URI: http://doi.org/10.3233/BD-150199
http://hdl.handle.net/11147/5793
ISSN: 0888-6008
Appears in Collections:Food Engineering / Gıda Mühendisliği
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

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