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Title: Bioactive Sheath/Core nanofibers containing olive leaf extract
Authors: Doğan, Gamze
Başal, Güldemet
Bayraktar, Oğuz
Özyıldız, Figen
Uzel, Ataç
Erdoğan, İpek
Keywords: Active agent release profile
Antimicrobial activity
Antioxidant activity
Coaxial electrospinning
Publisher: John Wiley and Sons Inc.
Source: Doğan, G., Başal, G., Bayraktar, O., Özyıldız, F., Uzel, A., and Erdoğan, İ. (2016). Bioactive Sheath/Core nanofibers containing olive leaf extract. Microscopy Research and Technique, 79(1), 38-49. doi:10.1002/jemt.22603
Abstract: This study aimed at producing silk fibroin (SF)/hyaluronic acid (HA) and olive leaf extract (OLE) nanofibers with sheath/core morphology by coaxial electrospinning method, determining their antimicrobial properties, and examining release profiles of OLE from these coaxial nanofibers. Optimum electrospinning process and solution parameters were determined to obtain uniform and bead-free coaxial nanofibers. Scanning electron microscopy and transmission electron microscopy (TEM) were used to characterize the morphology of the nanofibers. The antimicrobial activities of nanofibers were tested according to AATCC test method 100. Total phenolic content and total antioxidant activity were tested using in vitro batch release system. The quality and quantity of released components of OLE were determined by high-performance liquid chromatography. The changes in nanofibers were examined by Fourier-transform infrared spectroscopy. Uniform and bead-free nanofibers were produced successfully. TEM images confirmed the coaxial structure. OLE-loaded nanofibers demonstrated almost perfect antibacterial activities against both of gram-negative and gram-positive bacteria. Antifungal activity against C. albicans was rather poor. After a release period of 1 month, it was observed that ∼70-95% of the OLE was released from nanofibers and it was still bioactive. Overall results indicate that the resultant shell/core nanofibers have a great potential to be used as biomaterials.
ISSN: 1059-910X
Appears in Collections:Bioengineering / Biyomühendislik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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