Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5599
Title: Master regulators of posttranscriptional gene expression are subject to regulation
Authors: Hamid, Syed Muhammad
Akgül, Bünyamin
Keywords: Biological transport
Cytoplasm
Gene expression regulation
MicroRNAs
RNA
Issue Date: 2014
Publisher: Humana Press
Source: Hamid, S. M., and Akgül, B. (2014). Master regulators of posttranscriptional gene expression are subject to regulation. Methods in Molecular Biology, 1107, 303-310. doi:10.1007/978-1-62703-748-8_18
Abstract: MicroRNAs (miRNAs) are small noncoding RNAs of 17-25 nt in length that control gene expression posttranscriptionally. As master regulators of posttranscriptional gene expression, miRNAs themselves are subject to tight regulation at multiple steps. The most common mechanisms include miRNA transcription, processing, and localization. Additionally, intricate feedback loops between miRNAs and transcription factors result in unidirectional, reciprocal, or self-directed elegant control mechanisms. In this chapter, we focus on the posttranscriptional regulatory mechanisms that generate miRNAs whose sequence might be slightly different from the miRNA-coding sequences. Hopefully, this information will be helpful in the discovery of novel miRNAs as well as in the analysis of deep-sequencing data and ab initio prediction of miRNAs. © Springer Science+Business Media New York 2014.
URI: http://doi.org/10.1007/978-1-62703-748-8_18
http://hdl.handle.net/11147/5599
ISSN: 1940-6029
1064-3745
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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