Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5574
Title: PH- and temperature-responsive amphiphilic diblock copolymers of 4-vinylpyridine and oligoethyleneglycol methacrylate synthesized by RAFT polymerization
Authors: Topuzogulları, Murat
Bulmuş, Volga
Dalgakıran, Eray
Dinçer, Sevil
Keywords: Amphiphilic block copolymers
RAFT polymerization
Stimuli-responsive
Living polymerization
Issue Date: Jan-2014
Publisher: Elsevier Ltd.
Source: Topuzoğulları, M., Bulmuş, V., Dalgakıran, E., and Dinçer, S. (2014). PH- and temperature-responsive amphiphilic diblock copolymers of 4-vinylpyridine and oligoethyleneglycol methacrylate synthesized by RAFT polymerization. Polymer, 55(2), 525-534. doi:10.1016/j.polymer.2013.12.040
Abstract: Diblock copolymers of 4-vinylpyridine (4VP) and oligoethyleneglycol methyl ether methacrylate (OEGMA) were synthesized for the first time using RAFT polymerization technique as potential drug delivery systems. Effects of the number of ethylene glycol units in OEGMA, chain length of hydrophobic P4VP block, pH, concentration and temperature on the solution behavior of the copolymers were investigated comprehensively. Copolymer chains formed micelles at pH values higher than 5 whereas unimeric polymers were observed to exist below pH 5, owing to the repulsion between positively charged P4VP blocks. The size of the micelles was dependent on the relative length of blocks, P4VP and POEGMA. Thermo-responsive properties of copolymers were investigated depending on the pH and length of P4VP block. The increase in the length of P4VP block decreased the LCST substantially at pH 7. At pH 3, LCST of copolymers shifted to higher temperatures due to the increased interaction of copolymers with water through positively charged P4VP block.
URI: https://doi.org/10.1016/j.polymer.2013.12.040
http://hdl.handle.net/11147/5574
ISSN: 0032-3861
Appears in Collections:Chemical Engineering / Kimya Mühendisliği
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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