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Title: Targeting FoxM1 transcription factor in T-cell acute lymphoblastic leukemia cell line
Authors: Tüfekçi, Özlem
Kartal Yandım, Melis
Ören, Hale
İrken, Gülersu
Baran, Yusuf
Keywords: Dexamethasone
Jurkat cells
Siomycin A
T-cell acute lymphoblastic leukemia
Issue Date: Mar-2015
Publisher: Elsevier Ltd.
Source: Tüfekçi, Ö., Kartal Yandım, M., Ören, H., İrken, G. and Baran, Y. (2015). Targeting FoxM1 transcription factor in T-cell acute lymphoblastic leukemia cell line. Leukemia Research, 39(3), 342-347. doi:10.1016/j.leukres.2014.12.005
Abstract: The Forkhead box protein M1 (FoxM1) is an important transcription factor having significant roles in various cellular events. FoxM1 overexpression has been reported to be related with many types of cancer. However, it is not known whether it contributes to oncogenesis of acute lymphoblastic leukemia. Siomycin A, a thiazol antibiotic, is known to inhibit FoxM1 transcriptional activity. In this study, we aimed to determine gene expression levels of FoxM1 in Jurkat cells (T-cell acute lymphoblastic leukemia cell line) and therapeutic potential of targeting FoxM1 by siomycin A alone and in combination with dexamethasone which improves the survival of children with T-cell acute lymphoblastic leukemia (ALL). We also examined the molecular mechanisms of siomycin A and dexamethasone-induced cell death in Jurkat cells. We demonstrated that FoxM1 mRNA is highly expressed in Jurkat cells. Dexamethasone and siomycin A caused a significant reduction in gene expression levels of FoxM1 in Jurkat cells. Targeting FoxM1 by siomycin A and dexamethasone caused a significant decrease in T-ALL cell line proliferation through induction of G1 cell cycle arrest. All these findings suggest a possible role of FoxM1 in T-cell ALL pathogenesis and represent FoxM1 as an attractive target for T-cell ALL therapy. © 2014 Elsevier Ltd.
ISSN: 0145-2126
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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