Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5513
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dc.contributor.authorCan, Geylani-
dc.contributor.authorÇakır, Zeynep-
dc.contributor.authorKartal, Melis-
dc.contributor.authorGündüz, Ufuk-
dc.contributor.authorBaran, Yusuf-
dc.date.accessioned2017-05-15T13:58:47Z-
dc.date.available2017-05-15T13:58:47Z-
dc.date.issued2012-07-
dc.identifier.citationCan, G., Çakır, Z., Kartal, M., Gündüz, U. ,and Baran, Y. (2012). Apoptotic effects of resveratrol, a grape polyphenol, on imatinib-sensitive and resistant K562 chronic myeloid leukemia cells. Anticancer research, 32(7), 2673-2678.en_US
dc.identifier.issn1791-7530-
dc.identifier.issn0250-7005-
dc.identifier.urihttp://hdl.handle.net/11147/5513-
dc.description.abstractTo examine the antiproliferative and apoptotic effects of resveratrol on imatinib-sensitive and imatinib-resistant K562 chronic myeloid leukemia cells. Antiproliferative effects of resveratrol were determined by the 3-Bis[2-methoxy-4-nitro-5-sulphophenyl]-2H-tetrazolium-5-carboxanilide inner salt (XTT) cell proliferation assay. Apoptotic effects of resveratrol on sensitive K562 and resistant K562/IMA-3 cells were determined through changes in caspase-3 activity, loss of mitochondrial membrane potential (MMP), and apoptosis by annexin V-(FITC). The concentrations of resveratrol that inhibited cell growth by 50% (IC(50)) were calculated as 85 and 122 μM for K562 and K562/IMA-3 cells, respectively. There were 1.91-, 7.42- and 14.73-fold increases in loss of MMP in K562 cells treated with 10, 50, and 100 μM resveratrol, respectively. The same concentrations of resveratrol resulted in 2.21-, 3.30- and 7.65-fold increases in loss of MMP in K562/IMA-3 cells. Caspase-3 activity increased 1.04-, 2.77- and 4.8-fold in K562 and 1.02-, 1.41- and 3.46-fold in K562/IMA-3 cells in response to the same concentrations of resveratrol, respectively. Apoptosis was induced in 58.7%- and 43.3% of K562 and K562/IMA-3 cells, respectively, in response to 100 μM resveratrol. Taken together these results may suggest potential use of resveratrol in CML, as well as in patients with primary and/or acquired resistance to imatinib.en_US
dc.language.isoenen_US
dc.publisherInternational Institute of Anticancer Researchen_US
dc.relation.ispartofAnticancer Researchen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntineoplastic agenten_US
dc.subjectChronic myeloid leukemiaen_US
dc.subjectResveratrolen_US
dc.subjectStilbene derivativeen_US
dc.subjectCell growthen_US
dc.subjectImatiniben_US
dc.titleApoptotic effects of resveratrol, a grape polyphenol, on imatinib-sensitive and resistant K562 chronic myeloid leukemia cellsen_US
dc.typeArticleen_US
dc.authoridTR119193en_US
dc.departmentIzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume32en_US
dc.identifier.issue7en_US
dc.identifier.startpage2673en_US
dc.identifier.endpage2678en_US
dc.identifier.wosWOS:000306254300031
dc.identifier.scopusSCOPUS:2-s2.0-84867130707
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
crisitem.author.deptDepartment of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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