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Title: An update on molecular biology and drug resistance mechanisms of multiple myeloma
Authors: Mutlu, Pelin
Kiraz, Yağmur
Gündüz, Ufuk
Baran, Yusuf
Keywords: Drug resistance
Molecular aspects
Multiple myeloma
Targeted drug delivery
Publisher: Elsevier Ltd.
Source: Mutlu, P., Kiraz, Y., Gündüz, U., and Baran, Y. (2015). An update on molecular biology and drug resistance mechanisms of multiple myeloma. Critical Reviews in Oncology/Hematology, 96(3), 413-424. doi:10.1016/j.critrevonc.2015.07.003
Abstract: Multiple myeloma (MM), a neoplasm of plasma cells, is the second most common hematological malignancy. Incidance rates increase after age 40. MM is most commonly seen in men and African-American population. There are several factors to this, such as obesity, environmental factors, family history, genetic factors and monoclonal gammopathies of undetermined significance (MGUS) that have been implicated as potentially etiologic. Development of MM involves a series of complex molecular events, including chromosomal abnormalities, oncogene activation and growth factor dysregulation. Chemotherapy is the most commonly used treatment strategy in MM. However, MM is a difficult disease to treat because of its marked resistance to chemotherapy. MM has been shown to be commonly multidrug resistance (MDR)-negative at diagnosis and associated with a high incidence of MDR expression at relapse. This review deals with the molecular aspects of MM, drug resistance mechanisms during treatment and also possible new applications for overcoming drug resistance. © 2015 Elsevier Ireland Ltd.
ISSN: 1040-8428
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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