Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5295
Title: miR-17 in imatinib resistance and response to tyrosine kinase inhibitors in chronic myeloid leukemia cells
Authors: Fıratlıgil, Burcu
Biray Avcı, Çığır
Baran, Yusuf
Fıratlıgil, Burcu
Baran, Yusuf
Izmir Institute of Technology. Molecular Biology and Genetics
Keywords: Chronic myeloid leukemia
Dasatinib
Drug resistance
Imatinib
MicroRNAs
Nilotinib
Issue Date: Apr-2013
Publisher: Zerbinis Medical Publications
Source: Fıratlıgil, B., Biray Avcı, Ç., and Baran, Y. (2013). miR-17 in imatinib resistance and response to tyrosine kinase inhibitors in chronic myeloid leukemia cells. Journal of B.U.ON., 18(2), 437-441.
Abstract: In this study we examined the expression levels of miR-17 which possesses oncogenic activities through downregulation of CDKN1A, p21 and E2F1 tumor suppressor genes, in imatinib sensitive and resistant chronic myeloid leukemia (CML) cells. On the other hand, we also determined the expression levels of miR-17 in response to tyrosine kinase inhibitors imatinib, nilotinib and dasatinib used for the treatment of CML. Methods: The expression profiles of miR-17 were analysed by Stem-Loop reverse transcription (RT) polymerase chain reaction (PCR). Results: The results revealed significant increase in the expression levels of miR-17 in imatinib sensitive and resistant cells compared to peripheral blood mononuclear cells (PBMCs). On the other hand, significant decrease was observed in miR-17 levels in response to imatinib, nilotinib and dasatinib. Conclusion: These results may imply that miR-17 can be used for diagnosis and treatment of CML.
URI: http://hdl.handle.net/11147/5295
ISSN: 1107-0625
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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