Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5285
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dc.contributor.authorKiper, Hatice Demet-
dc.contributor.authorTezcanlı Kaymaz, Burçin-
dc.contributor.authorAdan Gökbulut, Aysun-
dc.contributor.authorSelvi, Nur-
dc.contributor.authorBiray Avcı, Çığır-
dc.contributor.authorKosova, Buket-
dc.contributor.authorİskender, Güniz-
dc.contributor.authorKartal Yandım, Melis-
dc.contributor.authorGündüz, Cumhur-
dc.contributor.authorŞahin, Fahri-
dc.contributor.authorBaran, Yusuf-
dc.contributor.authorSaydam, Güray-
dc.date.accessioned2017-04-11T10:31:38Z
dc.date.available2017-04-11T10:31:38Z
dc.date.issued2013-07
dc.identifier.citationKiper, H. D., Tezcanlı Kaymaz, B., Adan Gökbulut, A., Selvi, N., Biray Avcı, Ç., Kosova, B., İskender, G., Kartal Yandım, M., Gündüz, C., Şahin, F., Baran, Y., and Saydam, G. (2013). STAT pathway in the regulation of zoledronic acid-induced apoptosis in chronic myeloid leukemia cells. Biomedicine and Pharmacotherapy, 67(6), 527-532. doi:10.1016/j.biopha.2013.04.006en_US
dc.identifier.issn0753-3322
dc.identifier.issn0753-3322-
dc.identifier.urihttp://doi.org/10.1016/j.biopha.2013.04.006
dc.identifier.urihttp://hdl.handle.net/11147/5285
dc.description.abstractIn this study, we aimed to evaluate the cytotoxic and apoptotic effects of zoledronic acid on K562 chronic myeloid leukemia (CML) cells and to examine the roles of STAT genes on zoledronic acid-induced apoptosis. The results showed that zoledronic acid decreased proliferation, and induced apoptosis in K562 cells in a dose- and time-dependent manner. mRNA and protein levels of STAT3, -5A and -5B genes were significantly reduced in zoledronic acid-treated K562 cells. These data indicated that STAT inhibition by zoledronic acid may be therapeutic in CML patients following the confirmation with clinical studies. © 2013 Elsevier Masson SAS.en_US
dc.language.isoenen_US
dc.publisherElsevier Ltd.en_US
dc.relation.ispartofBiomedicine and Pharmacotherapyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectZoledronic aciden_US
dc.subjectChronic myeloid leukemiaen_US
dc.subjectSTATsen_US
dc.subjectMessenger RNAen_US
dc.titleSTAT pathway in the regulation of zoledronic acid-induced apoptosis in chronic myeloid leukemia cellsen_US
dc.typeArticleen_US
dc.authoridTR119193en_US
dc.institutionauthorAdan Gökbulut, Aysun-
dc.institutionauthorİskender, Güniz-
dc.institutionauthorKartal Yandım, Melis-
dc.institutionauthorBaran, Yusuf-
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume67en_US
dc.identifier.issue6en_US
dc.identifier.startpage527en_US
dc.identifier.endpage532en_US
dc.identifier.wosWOS:000324098000012en_US
dc.identifier.scopus2-s2.0-84880949133en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.biopha.2013.04.006-
dc.identifier.pmid23725755en_US
dc.relation.doi10.1016/j.biopha.2013.04.006en_US
dc.coverage.doi10.1016/j.biopha.2013.04.006en_US
dc.identifier.wosqualityQ3-
dc.identifier.scopusqualityQ2-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairetypeArticle-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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