Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5133
Title: Dynamic nuclear polarization of spherical nanoparticles
Authors: Akbey, Ümit
Altın, Burcu
Linden, Arne
Özçelik, Serdar
Gradzielski, Michael
Oschkinat, Hartmut
Keywords: Catalysis
Electrons
Amino acids
Contrast media
Silicon dioxide
Static electricity
Issue Date: Dec-2013
Publisher: Royal Society of Chemistry
Source: Akbey, Ü., Altın, B., Linden, A., Özçelik, S., Gradzielski, M., and Oschkinat, H. (2013). Dynamic nuclear polarization of spherical nanoparticles. Physical Chemistry Chemical Physics, 15(47), 20706-20716. doi:10.1039/c3cp53095g
Abstract: Spherical silica nanoparticles of various particle sizes (∼10 to 100 nm), produced by a modified Stoeber method employing amino acids as catalysts, are investigated using Dynamic Nuclear Polarization (DNP) enhanced Nuclear Magnetic Resonance (NMR) spectroscopy. This study includes ultra-sensitive detection of surface-bound amino acids and their supramolecular organization in trace amounts, exploiting the increase in NMR sensitivity of up to three orders of magnitude via DNP. Moreover, the nature of the silicon nuclei on the surface and the bulk silicon nuclei in the core (sub-surface) is characterized at atomic resolution. Thereby, we obtain unique insights into the surface chemistry of these nanoparticles, which might result in improving their rational design as required for promising applications, e.g. as catalysts or imaging contrast agents. The non-covalent binding of amino acids to surfaces was determined which shows that the amino acids not just function as catalysts but become incorporated into the nanoparticles during the formation process. As a result only three distinct Q-types of silica signals were observed from surface and core regions. We observed dramatic changes of DNP enhancements as a function of particle size, and very small particles (which suit in vivo applications better) were hyperpolarized with the best efficiency. Nearly one order of magnitude larger DNP enhancement was observed for nanoparticles with 13 nm size compared to particles with 100 nm size. We determined an approximate DNP penetration-depth (∼4.2 or ∼5.7 nm) for the polarization transfer from electrons to the nuclei of the spherical nanoparticles. Faster DNP polarization buildup was observed for larger nanoparticles. Efficient hyperpolarization of such nanoparticles, as achieved in this work, can be utilized in applications such as magnetic resonance imaging (MRI).
URI: https://doi.org/10.1039/c3cp53095g
http://hdl.handle.net/11147/5133
ISSN: 1463-9076
1463-9084
1463-9076
Appears in Collections:Chemistry / Kimya
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Files in This Item:
File Description SizeFormat 
5133.pdfMakale2.4 MBAdobe PDFThumbnail
View/Open
Show full item record

CORE Recommender

SCOPUSTM   
Citations

41
checked on Aug 10, 2022

WEB OF SCIENCETM
Citations

47
checked on Jun 21, 2022

Page view(s)

436
checked on Aug 15, 2022

Download(s)

94
checked on Aug 15, 2022

Google ScholarTM

Check

Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.