Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5089
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dc.contributor.authorKartal Yandım, Melis-
dc.contributor.authorSaydam, Güray-
dc.contributor.authorŞahin, Fahri-
dc.contributor.authorBaran, Yusuf-
dc.date.accessioned2017-03-17T13:44:54Z-
dc.date.available2017-03-17T13:44:54Z-
dc.date.issued2011-05-
dc.identifier.citationKartal, M., Saydam, G., Şahin, F., and Baran, Y. (2011). Resveratrol triggers apoptosis through regulating ceramide metabolizing genes in human K562 chronic myeloid leukemia cells. Nutrition and Cancer, 63(4), 637-644. doi:10.1080/01635581.2011.538485en_US
dc.identifier.issn0163-5581-
dc.identifier.issn1532-7914-
dc.identifier.urihttp://www.tandfonline.com/doi/abs/10.1080/01635581.2011.538485-
dc.identifier.urihttp://hdl.handle.net/11147/5089-
dc.description.abstractResveratrol, an important phytoalexin in many plants, has been reported to have cytotoxic effects on various types of cancer. Ceramide is a bioactive sphingolipid that regulates many signaling pathways, including cell growth and proliferation, senescence and quiescence, apoptosis, and cell cycle. Ceramides are generated by longevity assurance genes (LASS). Glucosylceramide synthase (GCS) and sphingosine kinase-1 (SK-1) enzymes can convert ceramides to antiapoptotic molecules, glucosylceramide, and sphingosine-1-phosphate, respectively. C8:ceramide, an important cell-permeable analogue of natural ceramides, increases intracellular ceramide levels significantly, while 1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) and SK-1 inhibitor increase accumulation of ceramides by inhibiting GCS and SK-1, respectively. Chronic myelogenous leukemia (CML) is a hematological disorder resulting from generation of BCR/ABL oncogene. In this study, we examined the roles of ceramide metabolizing genes in resveratrol-induced apoptosis in K562 CML cells. There were synergistic cytotoxic and apoptotic effects of resveratrol with coadministration of C8:ceramide, PDMP, and SK-1 inhibitor. Interestingly, there were also significant increases in expression levels of LASS genes and decreases in expression levels of GCS and SK-1 in K562 cells in response to resveratrol. Our data, in total, showed for the first time that resveratrol might kill CML cells through increasing intracellular generation and accumulation of apoptotic ceramides. Copyright © 2011, Taylor & Francis Group, LLC.en_US
dc.description.sponsorshipTurkish Society of Hematology; Turkish Academy of Sciencesen_US
dc.language.isoenen_US
dc.publisherRoutledgeen_US
dc.relation.ispartofNutrition and Canceren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTumor cell destructionen_US
dc.subjectChronic myeloid leukemiaen_US
dc.subjectCell strain K 562en_US
dc.subjectGene expressionen_US
dc.subjectDrug cytotoxicityen_US
dc.subjectAntineoplastic activityen_US
dc.subjectResveratrolen_US
dc.titleResveratrol triggers apoptosis through regulating ceramide metabolizing genes in human K562 chronic myeloid leukemia cellsen_US
dc.typeArticleen_US
dc.authoridTR119533en_US
dc.authoridTR119193en_US
dc.institutionauthorKartal Yandım, Melis-
dc.institutionauthorBaran, Yusuf-
dc.departmentIzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume63en_US
dc.identifier.issue4en_US
dc.identifier.startpage637en_US
dc.identifier.endpage644en_US
dc.identifier.wosWOS:000290970100016en_US
dc.identifier.scopus2-s2.0-79957604463en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1080/01635581.2011.538485-
dc.identifier.pmid21500096en_US
dc.relation.doi10.1080/01635581.2011.538485en_US
dc.coverage.doi10.1080/01635581.2011.538485en_US
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.languageiso639-1en-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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