Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5060
Title: Roles of ATR1 paralogs YMR279c and YOR378w in boron stress tolerance
Authors: Bozdağ, Gönensin Ozan
Uluışık, İrem
Gülcüler, Gülce Sıla
Karakaya, Hüseyin Çağlar
Koç, Ahmet
Keywords: ATR1
Boric acid
Boron
Stress response
Yeast
Issue Date: Jun-2011
Publisher: Elsevier Ltd.
Source: Bozdağ, G. Ö., Uluışık, İ., Gülcüler, G. S., Karakaya, H. C., and Koc, A. (2011). Roles of ATR1 paralogs YMR279c and YOR378w in boron stress tolerance. Biochemical and Biophysical Research Communications, 409(4), 748-751. doi:10.1016/j.bbrc.2011.05.080
Abstract: Boron is a necessary nutrient for plants and animals, however excess of it causes toxicity. Previously, Atr1 and Arabidopsis Bor1 homolog were identified as the boron efflux pump in yeast, which lower the cytosolic boron concentration and help cells to survive in the presence of toxic amount of boron. In this study, we analyzed ATR1 paralogs, YMR279c and YOR378w, to understand whether they participate in boron stress tolerance in yeast. Even though these genes share homology with ATR1, neither their deletion rendered cells boron sensitive nor their expression was significantly upregulated by boron treatment. However, expression of YMR279, but not YOR378w, from the constitutive GAPDH promoter on a high copy plasmid provided remarkable boron resistance by decreasing intracellular boron levels. Thus our results suggest the presence of a third boron exporter, YMR279c, which functions similar to ATR1 and provides boron resistance in yeast.
URI: https://doi.org/10.1016/j.bbrc.2011.05.080
http://hdl.handle.net/11147/5060
ISSN: 0006-291X
0006-291X
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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