Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5054
Title: Effect of cobalt-60 (? radiation) on multidrug-resistant multiple myeloma cell lines
Authors: Mutlu, Pelin
Baran, Yusuf
Ural, Ali Ugur
Avcu, Ferit
Dirican, Bahar
Beyzadeoglu, Murat
Gündüz, Ufuk
Baran, Yusuf
Izmir Institute of Technology. Molecular Biology and Genetics
Keywords: Drug resistance
Multiple myeloma
Radioresistance
RPMI-8226
U-266
Issue Date: Jul-2011
Publisher: Portland Press
Source: Mutlu, P., Baran, Y., Ural, A.U., Avcu, F., Dirican, B., Beyzadeoğlu, M., and Gündüz, U. (2011). Effect of cobalt-60 (γ radiation) on multidrug-resistant multiple myeloma cell lines. Cell Biology International, 35(7), 721-725. doi:10.1042/CBI20100061
Abstract: Emergence of resistance to chemotherapy and radiotherapy is a major obstacle for the successful treatment of MM (multiple myeloma). Prednisone, vincristine and melphalan are commonly used chemotherapeutic agents for the treatment of MM. In the current study, we examined the presence of possible cross-resistance between these drugs and gamma (γ) radiation. Prednisone, vincristine and melphalan resistant RPMI-8226 and U-266 MM cells were generated by stepwise increasing concentrations of the drugs. The sensitive and resistant cells were exposed to 200- and 800 cGy c radiation, and proliferation was examined by XTT {2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenylamino)carbonyl]-2H-t etrazolium hydroxide} assay. The results showed that Prednisone- and melphalan-resistant RPMI-8226 cells were also cross-resistant to 200 and 800 cGy γ radiation application, while vincristine-resistant cells did not show resistance. On the other hand, Prednisone-, vincristine- and melphalan-resistant U-266 cells showed cross-resistance to 200- and 800 cGy c radiation application. These results demonstrated that MM cells resistant to anticancer agents respond to radiation in different levels. These findings may be important in the clinical applications of radiation therapy in the treatment of vincristine resistant MM. © The Author(s) Journal compilation
URI: http://doi.org/10.1042/CBI20100061
http://hdl.handle.net/11147/5054
ISSN: 1065-6995
1065-6995
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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