Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/4967
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dc.contributor.authorAyyanan, Ayyakkannu-
dc.contributor.authorLaribi, Ouahiba-
dc.contributor.authorSchuepbach-Mallepell, Sonia-
dc.contributor.authorSchrick, Christina-
dc.contributor.authorGutierrez, Maria-
dc.contributor.authorTanos, Tamara-
dc.contributor.authorLefebvre, Gregory-
dc.contributor.authorRougemont, Jacques-
dc.contributor.authorYalçın Özuysal, Özden-
dc.contributor.authorBrisken, Cathrin-
dc.date.accessioned2017-03-03T11:55:17Z-
dc.date.available2017-03-03T11:55:17Z-
dc.date.issued2011-11-
dc.identifier.citationAyyanan, A., Laribi, O., Schuepbach-Mallepell, S., Schrick, C., Gutierrez, M., Tanos, T., Lefebvre, G., Rougemont, J., Yalçın Özuysal, Ö., and Brisken, C. (2011). Perinatal exposure to bisphenol A increases adult mammary gland progesterone response and cell number. Molecular Endocrinology, 25(11), 1915-1923. doi:10.1210/me.2011-1129en_US
dc.identifier.issn1944-9917-
dc.identifier.issn0888-8809-
dc.identifier.urihttp://doi.org/10.1210/me.2011-1129-
dc.identifier.urihttp://hdl.handle.net/11147/4967-
dc.description.abstractBisphenol A [BPA, 2,2,-bis (hydroxyphenyl) propane] is one of the highest-volume chemicals produced worldwide. It is detected in body fluids of more than 90% of the human population. Originally synthesized as an estrogenic compound, it is currently utilized to manufacture food and beverage containers resulting in uptake with food and drinks. There is concern that exposure to low doses of BPA, defined as less than or equal to 5 mg/kg body weight /d, may have developmental effects on various hormone-responsive organs including the mammary gland. Here, we asked whether perinatal exposure to a range of low doses of BPA is sufficient to alter mammary gland hormone response later on in life, with a possible impact on breast cancer risk. To mimic human exposure, we added BPA to the drinking water of C57/Bl6 breeding pairs. Analysis of the mammary glands of their daughters at puberty showed that estrogen-dependent transcriptional events were perturbed and the number of terminal end buds, estrogen-induced proliferative structures, was altered in a dose-dependent fashion. Importantly, adult females showed an increase in mammary epithelial cell numbers comparable to that seen in females exposed to diethylbestrol, a compound exposure to which was previously linked to increased breast cancer risk. Molecularly, the mRNAs encoding Wnt-4 and receptor activator of nuclear factor kB ligand, two key mediators of hormone function implicated in control of mammary stem cell proliferation and carcinogenesis, showed increased induction by progesterone in the mammary tissue of exposed mice. Thus, perinatal exposure to environmentally relevant doses of BPA alters long-term hormone response that may increase the propensity to develop breast cancer. © 2011 by The Endocrine Society.en_US
dc.description.sponsorshipSwiss Science Foundation (NRP50); Swiss Federal Public Health Officeen_US
dc.language.isoenen_US
dc.publisherThe Endocrine Societyen_US
dc.relation.ispartofMolecular Endocrinologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectWnt4 proteinen_US
dc.subjectBreast canceren_US
dc.subjectBisphenol Aen_US
dc.subjectRANK liganden_US
dc.subjectProgesteroneen_US
dc.titlePerinatal exposure to bisphenol a increases adult mammary gland progesterone response and cell numberen_US
dc.typeArticleen_US
dc.authoridTR103812en_US
dc.contributor.departmentIzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume25en_US
dc.identifier.issue11en_US
dc.identifier.startpage1915en_US
dc.identifier.endpage1923en_US
dc.identifier.wosWOS:000296591700008
dc.identifier.scopusSCOPUS:2-s2.0-80055009372
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1210/me.2011-1129-
dc.relation.doi10.1210/me.2011-1129en_US
dc.coverage.doi10.1210/me.2011-1129en_US
item.languageiso639-1en-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.openairetypeArticle-
crisitem.author.deptDepartment of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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