Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/4957
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dc.contributor.authorUluışık, İrem-
dc.contributor.authorKaya, Alaattin-
dc.contributor.authorFomenko, Dmitri E.-
dc.contributor.authorKarakaya, Hüseyin Çağlar-
dc.contributor.authorCarlson, Bradley A.-
dc.contributor.authorGladyshev, Vadim N.-
dc.contributor.authorKoç, Ahmet-
dc.date.accessioned2017-03-02T14:04:41Z-
dc.date.available2017-03-02T14:04:41Z-
dc.date.issued2011-11-
dc.identifier.citationUluışık, İ., Kaya, A., Fomenko, D. E., Karakaya, H. Ç., Carlson, B. A., Gladyshev, V. N., and Koç, A. (2011). Boron stress activates the general amino acid control mechanism and inhibits protein synthesis. PLoS ONE, 6(11). doi:10.1371/journal.pone.0027772en_US
dc.identifier.isbn1932-6203-
dc.identifier.issn1932-6203-
dc.identifier.urihttp://doi.org/10.1371/journal.pone.0027772-
dc.identifier.urihttp://hdl.handle.net/11147/4957-
dc.description.abstractBoron is an essential micronutrient for plants, and it is beneficial for animals. However, at high concentrations boron is toxic to cells although the mechanism of this toxicity is not known. Atr1 has recently been identified as a boron efflux pump whose expression is upregulated in response to boron treatment. Here, we found that the expression of ATR1 is associated with expression of genes involved in amino acid biosynthesis. These mechanisms are strictly controlled by the transcription factor Gcn4 in response to boron treatment. Further analyses have shown that boron impaired protein synthesis by promoting phosphorylation of eIF2α in a Gcn2 kinase dependent manner. The uncharged tRNA binding domain (HisRS) of Gcn2 is necessary for the phosphorylation of eIF2α in the presence of boron. We postulate that boron exerts its toxic effect through activation of the general amino acid control system and inhibition of protein synthesis. Since the general amino acid control pathway is conserved among eukaryotes, this mechanism of boron toxicity may be of general importance.en_US
dc.description.sponsorshipTÜBİTAK (104T213-110T917); TUBA-GEBIPen_US
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofPLoS ONEen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBoronen_US
dc.subjectATR1 proteinen_US
dc.subjectBiological markeren_US
dc.subjectTransfer RNAen_US
dc.subjectChemical stressen_US
dc.subjectAmino acid synthesisen_US
dc.titleBoron stress activates the general amino acid control mechanism and inhibits protein synthesisen_US
dc.typeArticleen_US
dc.authoridTR24898en_US
dc.authoridTR110769en_US
dc.institutionauthorUluışık, İrem-
dc.institutionauthorKaya, Alaattin-
dc.institutionauthorKarakaya, Hüseyin Çağlar-
dc.institutionauthorKoç, Ahmet-
dc.departmentIzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume6en_US
dc.identifier.issue11en_US
dc.identifier.wosWOS:000297555800033en_US
dc.identifier.scopus2-s2.0-81255195855en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1371/journal.pone.0027772-
dc.identifier.pmid22114689en_US
dc.relation.doi10.1371/journal.pone.0027772en_US
dc.coverage.doi10.1371/journal.pone.0027772en_US
local.message.claim2022-06-06T11:53:20.650+0300|||rp00417|||submit_approve|||dc_contributor_author|||None*
dc.identifier.scopusqualityQ1-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.openairetypeArticle-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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