Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/4499
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dc.contributor.authorGüneş, Hatice-
dc.contributor.authorMastro, Andrea M.-
dc.date.accessioned2016-03-31T12:53:13Z
dc.date.available2016-03-31T12:53:13Z
dc.date.issued1997-05
dc.identifier.citationGüneş, H., and Mastro, A. M. (1997). Prolactin receptor gene expression in rat splenocytes and thymocytes during oestrous cycle, pregnancy and lactation. Cell Proliferation, 30(5), 219-235. doi:10.1046/j.1365-2184.1997.00088.xen_US
dc.identifier.issn0960-7722
dc.identifier.issn0960-7722-
dc.identifier.urihttp://doi.org/10.1046/j.1365-2184.1997.00088.x
dc.identifier.urihttp://hdl.handle.net/11147/4499
dc.description.abstractMuch evidence suggests that prolactin (PRL) has an immunoregulatory function. Part of this evidence is that the receptors for PRL are present on lymphocytes. Probably the effects of PRL on cells of the immune system depend on the level and specific forms of PRL-R present on the target cells. Therefore, PRL-R expression at both protein and mRNA levels was examined during oestrous cycle, pregnancy and lactation using Western blotting and PCR analysis. Antibody to the long form of PRL-R detected 84 and 42 kDa protein bands in the spleen but only 84 kDa band in the thymus. The expression pattern of these two protein bands was different in the spleen, suggesting that these two isoforms of PRL-R long form are differentially regulated by the hormones of oestrous cycle. In addition, depending on the tissue, the level of mRNA for the short and long forms of PRL-R showed a significant change at different stages of oestrous cycle. Moreover, 42 and 84 kDa PRL-R bands were detected in both spleen and thymus throughout the pregnancy and lactation; however, the expression pattern of 84 kDa protein band was different between tissues. This finding suggests that each tissue exhibits differential response to hormones which affect PRL-R content.en_US
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Inc.en_US
dc.relation.ispartofCell Proliferationen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectProlactin receptoren_US
dc.subjectAnimal cellen_US
dc.subjectGene expressionen_US
dc.subjectAntibody detectionen_US
dc.subjectPolymerase chain reactionen_US
dc.titleProlactin receptor gene expression in rat splenocytes and thymocytes during oestrous cycle, pregnancy and lactationen_US
dc.typeArticleen_US
dc.authoridTR2082en_US
dc.institutionauthorGüneş, Hatice-
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume30en_US
dc.identifier.issue5en_US
dc.identifier.startpage219en_US
dc.identifier.endpage235en_US
dc.identifier.wosWOS:000071020900002en_US
dc.identifier.scopus2-s2.0-0030714089en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1111/j.1365-2184.1997.tb00936.x-
dc.identifier.pmid9420613en_US
dc.relation.doi10.1111/j.1365-2184.1997.tb00936.xen_US
dc.coverage.doi10.1111/j.1365-2184.1997.tb00936.xen_US
local.message.claim2022-06-03T16:41:13.434+0300*
local.message.claim|rp02904*
local.message.claim|submit_approve*
local.message.claim|dc_contributor_author*
local.message.claim|None*
dc.identifier.wosqualityQ1-
dc.identifier.scopusqualityN/A-
item.openairetypeArticle-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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