Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/2865
Title: Docetaxel/zoledronic acid combination triggers apoptosis synergistically through downregulating antiapoptotic Bcl-2 protein level in hormone-refractory prostate cancer cells
Authors: Karabulut, B.
Erten, C.
Gül, M. K.
Cengiz, E.
Karaca, B.
Küçükzeybek, Y.
Görümlü, G.
Atmaca, H.
Uzunoğlu, S.
Şanlı, U. A.
Baran, Yusuf
Uslu, R.
Baran, Yusuf
Izmir Institute of Technology. Molecular Biology and Genetics
Keywords: Zoledronic acid
Prostate cancer
Docetaxel
Bcl-2
DU-145
PC-3
Issue Date: Feb-2009
Publisher: John Wiley and Sons Inc.
Source: Karabulut, B., Erten, C., Gül, M. K., Cengiz, E., Karaca, B., Küçükzeybek, Y., Görümlü, G., Atmaca, H., Uzunoğlu, S., Şanlı, U. A., Baran, Y., and Uslu, R. (2009). Docetaxel/zoledronic acid combination triggers apoptosis synergistically through downregulating antiapoptotic Bcl-2 protein level in hormone-refractory prostate cancer cells. Cell Biology International, 33(2), 239-246. doi:10.1016/j.cellbi.2008.11.011
Abstract: Docetaxel, a semi-synthetic taxane analogue, is used effectively in the treatment of metastatic prostate cancer. Zoledronic acid, the most potent member of bisphosphonates, has shown pleiotropic anti-tumoral effects on prostate cancer cells. We have explored the possible additive/synergistic effects and the apoptotic pathways induced by combination treatment of docetaxel and zoledronic acid in hormone and drug refractory, PC-3 and DU-145 prostate cancer cells. Combination of docetaxel and zoledronic acid synergistically inhibits cell growth in PC-3 and DU-145 cells. Moreover, this effect was due to downregulation of antiapoptotic protein Bcl-2 in PC-3 and DU-145 cells. In conclusion, docetaxel/zoledronic acid combination is potentially a novel and effective approach for the treatment of prostate cancer.
URI: http://doi.org/10.1016/j.cellbi.2008.11.011
http://hdl.handle.net/11147/2865
ISSN: 1065-6995
1065-6995
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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