Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/2726
Title: Combination of fludarabine and imatinib induces apoptosis synergistically through loss of mitochondrial membrane potential and increases in caspase-3 enzyme activity in human K562 chronic myleloid leukemia cells
Authors: Baran, Yusuf
Öztekin, Coşkun
Başsoy, Esen Yonca
Baran, Yusuf
Başsoy, Esen Yonca
Izmir Institute of Technology. Molecular Biology and Genetics
Keywords: Apoptosis
BCR/ABL
Chronic myeloid leukemia
Fludarabine
Imatinib
Issue Date: Jun-2010
Publisher: Informa Healthcare
Source: Baran, Y., Öztekin, C., and Başsoy, E. Y. (2010). Combination of fludarabine and imatinib induces apoptosis synergistically through loss of mitochondrial membrane potential and increases in caspase-3 enzyme activity in human K562 chronic myleloid leukemia cells. Cancer Investigation, 28(6), 623-628. doi:10.3109/07357901003631056
Abstract: In this study, we aimed to show the synergistic apoptotic effects of imatinib/fludarabine combination in human K562 chronic myleloid leukemia (CML) cells. There was a significant increase in cytotoxicity of combination of imatinib and fludarabine as compared to any agent alone. On the other hand, combination of both agents induced apoptosis significantly as confirmed by increases in caspase-3 enzyme activity and decreases in mitochondrial membrane potential. As a summary, the results of this study strongly suggest that combination of imatinib and fludarabine induced cell death synergistically comparing to only imatinib or fludarabine in human K562 CML cells. Copyright © 2010 Informa Healthcare USA, Inc.
URI: http://doi.org/10.3109/07357901003631056
http://hdl.handle.net/11147/2726
ISSN: 0735-7907
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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