Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/2682
Title: Seleno L-methionine acts on cyclophosphamide-induced kidney toxicity
Authors: Ayhancı, Adnan
Güneş, Sibel
Şahintürk, Varol
Appak, Sıla
Uyar, Ruhi
Cengiz, Mustafa
Altuner, Yılmaz
Yaman, Suzan
Appak, Sıla
Izmir Institute of Technology. Molecular Biology and Genetics
Keywords: Cyclophosphamide
Cytoprotectivity
Kidney
Nephrotoxicity
Seleno L-methionine
Rattus
Issue Date: Aug-2010
Publisher: Humana Press
Source: Ayhancı, A., Güneş, S., Şahintürk, V., Appak, S., Uyar, R., Cengiz, M., Altuner, Y., and Yaman, S. (2010). Seleno L-methionine acts on cyclophosphamide-induced kidney toxicity. Biological Trace Element Research, 136(2), 171-179. doi:10.1007/s12011-009-8535-2
Abstract: The anticancer drug cyclophosphamide (CP) has nephrotoxic effects besides its urotoxicity, which both in turn limit its clinical utility. The nephrotoxicity of CP is less common compared to its urotoxicity, and not much importance has been given for the study of mechanism of CP-induced nephrotoxicity so far. Overproduction of reactive oxygen species (ROS) during inflammation is one of the reasons of the kidney injury. Selenoproteins play crucial roles in regulating ROS and redox status in nearly all tissues; therefore, in this study, the nephrotoxicity of CP and the possible protective effects of seleno L-methionine (SLM) on rat kidneys were investigated. Forty-two Sprague-Dawley rats were equally divided into six groups of seven rats each. The control group received saline, and other rats were injected with CP (100 mg/kg), SLM (0.5 or 1 mg/kg), or CP+ SLM intraperitoneally. Malondialdehyde (MDA) and glutathione (GSH) levels in kidney homogenates of rats were measured, and kidney tissues were examined under the microscope. CP-treated rats showed a depletion of renal GSH levels (28% of control), while CP+SLM-injected rats had GSH values close to the control group. MDA levels increased 36% of control following CP administration, which were significantly decreased after SLM treatment. Furthermore, these biochemical results were supported by microscopical observations. In conclusion, the present study not only points to the therapeutic potential of SLM in CP-induced kidney toxicity but also indicates a significant role for ROS and their relation to kidney dysfunction. © Humana Press Inc. 2009.
URI: http://doi.org/10.1007/s12011-009-8535-2
http://hdl.handle.net/11147/2682
ISSN: 0163-4984
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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