Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/2623
Title: The roles of thiol oxidoreductases in yeast replicative aging
Authors: Hacıoğlu, Elise
Esmer, Işıl
Fomenko, Dmitri E.
Gladyshev, Vadim N.
Koç, Ahmet
Keywords: Yeast
Oxidoreductase
Oxidation
Life span
Antioxidant
Aging
Issue Date: Nov-2010
Publisher: Elsevier Ltd.
Source: Hacıoğlu, E., Esmer, I., Fomenko, D. E., Gladyshev, V. N., and Koç, A. (2010). The roles of thiol oxidoreductases in yeast replicative aging. Mechanisms of Ageing and Development, 131(11-12), 692-699. doi:10.1016/j.mad.2010.09.006
Abstract: Thiol-based redox reactions are involved in the regulation of a variety of biological functions, such as protection against oxidative stress, signal transduction and protein folding. Some proteins involved in redox regulation have been shown to modulate life span in organisms from yeast to mammals. To assess the role of thiol oxidoreductases in aging on a genome-wide scale, we analyzed the replicative life span of yeast cells lacking known and candidate thiol oxidoreductases. The data suggest the role of several pathways in controlling yeast replicative life span, including thioredoxin reduction, protein folding and degradation, peroxide reduction, PIP3 signaling, and ATP synthesis. © 2010 Elsevier Ireland Ltd.
URI: http://doi.org/10.1016/j.mad.2010.09.006
http://hdl.handle.net/11147/2623
ISSN: 1872-6216
0047-6374
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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