Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/2298
Title: Protective effect of zinc on cyclophosphamide-induced hematoxicity and urotoxicity
Authors: Ayhancı, Adnan
Uyar, Ruhi
Aral, Erinç
Kabadere, Selda
Appak, Sıla
Appak, Sıla
Izmir Institute of Technology. Molecular Biology and Genetics
Keywords: Bladder
Cyclophosphamide
Hematopoietic system
Rat
Zinc
Issue Date: Dec-2008
Publisher: Humana Press
Source: Ayhancı, A., Uyar, R., Aral, E., Kabadere, S., and Appak, S. (2008). Protective effect of zinc on cyclophosphamide-induced hematoxicity and urotoxicity. Biological Trace Element Research, 126(1-3), 186-193. doi:10.1007/s12011-008-8189-5
Abstract: Cyclophosphamide (CP) is widely used for the treatment of neoplastic diseases; however, its toxicity causes dose-limiting side effects. Zinc (Zn) is an essential trace element and has important biological functions that control many cell processes including DNA synthesis, normal growth, reproduction, fetal development, bone formation, and wound healing. Therefore, the toxicity of CP and the possible protective effect of Zn on blood cells, bone marrow, and bladder of rat were investigated in this study. Intraperitoneal administration of 50, 100, or 150 mg/kg CP for 3 days caused, in a dose-dependent manner, reductions in the number of leukocytes, thrombocytes, and bone marrow nucleated cells and a serious urotoxicity. To explore whether CP-induced damages could be prevented by Zn, other groups of rats were pretreated with 4 or 8 mg/kg ZnCl2 intraperitoneally for 3 days then challenged with respective doses of CP plus ZnCl2 on day 4 for three more days. The results indicated that treatment of rats with Zn could dose-dependently alleviate CP-induced toxicities on blood cells, bone marrow cells, and urinary bladder. We suggest that Zn could be a potentially effective drug in the prevention of CP-related hematoxicity and urotoxicity.
URI: http://doi.org/10.1007/s12011-008-8189-5
http://hdl.handle.net/11147/2298
ISSN: 0163-4984
0163-4984
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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