Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/2270
Title: Methionine sulfoxide reduction and the aging process
Authors: Koç, Ahmet
Gladyshev, Vadim N.
Keywords: Aging
Anaerobic
Methionine sulfoxide reductase
Yeast life span
Reactive oxygen species
Issue Date: Apr-2007
Publisher: John Wiley and Sons Inc.
Source: Koç, A., and Gladyshev, V. N. (2007). Methionine sulfoxide reduction and the aging process. Annals of the New York Academy of Sciences, 1100, 383-386. doi:10.1196/annals.1395.042
Abstract: Aging has been described for multicellular and asymmetrically dividing organisms, but the mechanisms are poorly understood. Oxidation of proteins is considered to be one of the major factors that leads to aging. Oxidative damage to proteins results in the oxidation of certain amino acid residues, among which oxidation of sulfur-containing amino acids, methionine and cysteine, is notable because of the susceptibility of these residues to damage, and occurrence of repair mechanisms. Methionine sulfoxide reductases, MsrA and MsrB, are thioredoxin-dependent oxidoreductases that reduce oxidized forms of methionine, methionine sulfoxides, in a stereospecific manner. These enzymes are present in all cell types and have shown to be regulating life spans in mammals, insects, and yeast. Here, their roles in modulating yeast life span are discussed.
URI: http://doi.org/10.1196/annals.1395.042
http://hdl.handle.net/11147/2270
ISSN: 0077-8923
0077-8923
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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