Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/2269
Title: Effects of deleting mitochondrial antioxidant genes on life span
Authors: Ünlü, Ercan Selçuk
Koç, Ahmet
Ünlü, Ercan Selçuk
Koç, Ahmet
Izmir Institute of Technology. Molecular Biology and Genetics
Keywords: Aging
Antioxidant genes
Mitochondria
Reactive oxygen species
Issue Date: Apr-2007
Publisher: John Wiley and Sons Inc.
Source: Ünlü, E. S., and Koç, A. (2007). Effects of deleting mitochondrial antioxidant genes on life span. Annals of the New York Academy of Sciences, 1100, 505-509. doi:10.1196/annals.1395.055
Abstract: Reactive oxygen species (ROS) damage biomolecules, accelerate aging, and shorten life span, whereas antioxidant enzymes mitigate these effects. Because mitochondria are a primary site of ROS generation and also a primary target of ROS attack, they have become a major focus area of aging studies. Here, we employed yeast genetics to identify mitochondrial antioxidant genes that are important for replicative life span. In our studies, it was found that among the known mitochondrial antioxidant genes (TTR1, CCD1, SOD1, GLO4, TRR2, TRX3, CCS1, SOD2, GRX5, PRX1), deletion of only three genes, SOD1 (Cu, Zn superoxide dismutase), SOD2 (Manganese-containing superoxide dismutase), and CCS1 (Copper chaperone), shortened the life span enormously. The life span decreased 40% for Δsod1 mutant, 72% for Δsod2 mutant, and 50% for Δccs1 mutant. Deletion of the other genes had little or no effect on life span.
URI: http://doi.org/10.1196/annals.1395.055
http://hdl.handle.net/11147/2269
ISSN: 0077-8923
0077-8923
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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