Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/2004
Title: Silk fibroin as a novel coating material for controlled release of theophylline
Authors: Bayraktar, Oğuz
Malay, Özge
Özgarip, Yarkın
Batıgün, Ayşegül
Bayraktar, Oğuz
Malay, Özge
Özgarip, Yarkın
Batıgün, Ayşegül
Izmir Institute of Technology. Chemical Engineering
Keywords: Aqueous coating
Controlled release
Cross-linking
Silk fibroin
Theophylline
Issue Date: Aug-2005
Publisher: Elsevier Ltd.
Source: Bayraktar, O., Malay, O., Özgarip, Y., and Batigün, A. (2005). Silk fibroin as a novel coating material for controlled release of theophylline. Silk fibroin as a novel coating material for controlled release of theophylline, 60(3), 373-381. doi:10.1016/j.ejpb.2005.02.002
Abstract: The aim of this study was to explore potential use of the silk fibroin (SF) as an aqueous coating material for theophylline tablets. We have examined the film forming and coating properties of heat-treated fibroin, SF solution having different amounts of polyethylene glycol (PEG) and 1-ethyl-3-(3-dimethyl aminopropyl)carbodiimide (EDC) cross-linked SF. Heat-treated SF material possessed a brittle structure, which resulted in poor film forming and coating properties. The optimum PEG amount in SF solution was determined as 17% (by weight) for an acceptable film forming and zero order release profile. EDC cross-linked SF has shown a very good film forming and coating property with a potential for sustaining the drug release from coated theophylline tablets. Dissolution data for coated theophylline tablets were analyzed using Ritger and Peppas equation to describe the mechanism of drug release. Drug release from the EDC coated tablets followed zero-order kinetics. Release rate constants were found to be 0.26, 0.19, 0.16% min-1 for single-coated, double coated, and triple coated tablets, respectively. These results clearly demonstrated that silk fibroin has high utility as a novel aqueous coating material for controlled release products.
URI: http://doi.org/10.1016/j.ejpb.2005.02.002
http://hdl.handle.net/11147/2004
ISSN: 0939-6411
0939-6411
Appears in Collections:Chemical Engineering / Kimya Mühendisliği
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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