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https://hdl.handle.net/11147/1893
Title: | Protoporphyrin IX-loaded magnetoliposomes as a potential drug delivery system for photodynamic therapy: Fabrication, characterization and in vitro study | Authors: | Başoğlu, Harun Bilgin, Mehmet Dinçer Demir, Mustafa Muammer |
Keywords: | Protoporphyrin IX Magnetoliposomes Iron oxide nanoparticles Photodynamic therapy MCF-7 cells |
Publisher: | Elsevier Ltd. | Source: | Başoğlu, H., Bilgin, M. D., and Demir, M. M. (2016). Protoporphyrin IX-loaded magnetoliposomes as a potential drug delivery system for photodynamic therapy: Fabrication, characterization and in vitro study. Photodiagnosis and Photodynamic Therapy, 13, 81-90. doi:10.1016/j.pdpdt.2015.12.010 | Abstract: | Protoporphyrin IX (PpIX) is a well-known photosensitizer that has great potential for use in photodynamic therapy (PDT). However, aggregation behavior of PpIX in neutral water makes it inappropriate for physiological studies. PpIX-loaded magnetoliposomes (MLs) were fabricated to increase PpIX biocompatibility. PpIX-loaded ML physical properties were characterized, and PpIX-loaded ML drug release behavior was investigated under the influence of an external magnetic field and heat. Toxicity and photodynamic effects of the complex were also examined using in vitro experiments with MCF-7 human breast cancer cells. The magnetoliposomes were prepared with DPPC, DSPE-PEG2000 lipids and Fe3O4 nanoparticles. The toxicity and in vitro photodynamic effects of the PpIX-loaded MLs at various concentrations were studied using the MCF-7 cell line. | URI: | http://dx.doi.org/doi:10.1016/j.pdpdt.2015.12.010 http://hdl.handle.net/11147/1893 |
ISSN: | 1572-1000 |
Appears in Collections: | Materials Science and Engineering / Malzeme Bilimi ve Mühendisliği PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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File | Description | Size | Format | |
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1893-main.pdf | Accepted Manuscript | 1.47 MB | Adobe PDF | View/Open |
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