Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/1893
Title: Protoporphyrin IX-loaded magnetoliposomes as a potential drug delivery system for photodynamic therapy: Fabrication, characterization and in vitro study
Authors: Başoğlu, Harun
Bilgin, Mehmet Dinçer
Demir, Mustafa Muammer
Demir, Mustafa Muammer
Izmir Institute of Technology. Materials Science and Engineering
Keywords: Protoporphyrin IX
Magnetoliposomes
Iron oxide nanoparticles
Photodynamic therapy
MCF-7 cells
Issue Date: Mar-2016
Publisher: Elsevier Ltd.
Source: Başoğlu, H., Bilgin, M. D., and Demir, M. M. (2016). Protoporphyrin IX-loaded magnetoliposomes as a potential drug delivery system for photodynamic therapy: Fabrication, characterization and in vitro study. Photodiagnosis and Photodynamic Therapy, 13, 81-90. doi:10.1016/j.pdpdt.2015.12.010
Abstract: Protoporphyrin IX (PpIX) is a well-known photosensitizer that has great potential for use in photodynamic therapy (PDT). However, aggregation behavior of PpIX in neutral water makes it inappropriate for physiological studies. PpIX-loaded magnetoliposomes (MLs) were fabricated to increase PpIX biocompatibility. PpIX-loaded ML physical properties were characterized, and PpIX-loaded ML drug release behavior was investigated under the influence of an external magnetic field and heat. Toxicity and photodynamic effects of the complex were also examined using in vitro experiments with MCF-7 human breast cancer cells. The magnetoliposomes were prepared with DPPC, DSPE-PEG2000 lipids and Fe3O4 nanoparticles. The toxicity and in vitro photodynamic effects of the PpIX-loaded MLs at various concentrations were studied using the MCF-7 cell line.
URI: http://dx.doi.org/doi:10.1016/j.pdpdt.2015.12.010
http://hdl.handle.net/11147/1893
ISSN: 1572-1000
Appears in Collections:Materials Science and Engineering / Malzeme Bilimi ve Mühendisliği
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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