Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/13775
Title: Mitigation potential of zingerone and rutin on toxicity mechanisms of nickel to zebrafish based on morphological, DNA damage and apoptosis outcome analysis
Authors: Köktürk, Mine
Yıldırım, Serkan
Atamanalp, Muhammed
Kılıçoğlu, Metin
Uçar, Arzu
Özhan, Güneş
Alak, Gonca
Keywords: Zingerone
Rutin
8-OHdG
Caspase 3
Necrosis
Publisher: Elsevier
Abstract: Although nickel (Ni) is an important cofactor for various enzymes in biological systems, it can cause serious problems when insufficient or excessive in an organism. Therefore, it is very important to investigate Ni in biological systems, especially in cells with its related pathogenic mechanism. This study was carried out to demonstrate the effects of zingerone (ZO) and rutin (RN) administration against nickel chloride (NiCl2) toxicity on neurobehavioral performance and brain oxidative status in zebrafish (Danio rerio) embryos/larvae on histological perspective. The experimental design of the study, which included twenty groups of fish, each containing 10 embryos, was prepared as semi-static and the trial continued for 96 hpf. In the obtained findings, it was determined that ZO and RN had a mitigating effect in this toxicity table where Ni caused oxidative stress in zebrafish larvae, induced DNA damage and apoptosis. A similar picture is valid for malformation processes as well as survival and hatching rates. These results showed that nickel is toxic to developing embryos via acting different mechanisms. In conclusion, we observed that ZO and RN have a greater effect on physiology, DNA damage and apoptosis than gross morphology, with a significant ameliorative effect.
URI: https://doi.org/10.1016/j.jtemb.2023.127268
https://hdl.handle.net/11147/13775
ISSN: 0946-672X
1878-3252
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Files in This Item:
File SizeFormat 
1-s2.0-S0946672X2300144X-main.pdf
  Until 2025-01-01
13.33 MBAdobe PDFView/Open    Request a copy
Show full item record



CORE Recommender

SCOPUSTM   
Citations

2
checked on Dec 6, 2024

WEB OF SCIENCETM
Citations

2
checked on Dec 7, 2024

Page view(s)

182
checked on Dec 9, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.