Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/13632
Title: Long noncoding RNAs in human cancer and apoptosis
Authors: Erdoğan, İpek
Sweef, Osama
Akgül, Bünyamin
Keywords: lncRNAs
Apoptosis
Cancer
Gene regulation
DNA
Nucleotides
Publisher: Bentham Science Publishers
Abstract: Genome annotations have uncovered the production of at least one transcript from nearly all loci in the genome at some given time throughout the development. Surprisingly, many of these transcripts do not code for proteins and are relatively long in size, thus called long noncoding RNAs (lncRNAs). Next- and third-generation sequencing technologies have amassed numerous lncRNAs expressed under different phenotypic conditions, yet many remain to be functionally characterized. LncRNAs regulate gene expression by functioning as scaffold, decoy, signaling, and guide molecules both at the transcriptional and post-transcriptional levels, interacting with different types of macromolecules, such as proteins, DNA, and RNA. Here, we review the potential regulatory role of lncRNAs in apoptosis and cancer as some of these lncRNAs may have the diagnostic and therapeutic potential in cancer.
URI: https://doi.org/10.2174/1389201023666220624094950
https://hdl.handle.net/11147/13632
ISSN: 1389-2010
1873-4316
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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