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https://hdl.handle.net/11147/13602
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DC Field | Value | Language |
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dc.contributor.author | Aldemir Dikici, Betül | - |
dc.contributor.author | Chen, Min-Chia | - |
dc.contributor.author | Dikici, Serkan | - |
dc.contributor.author | Chiu, Hsien-Chung | - |
dc.contributor.author | Claeyssens, Frederik | - |
dc.date.accessioned | 2023-07-27T19:49:58Z | - |
dc.date.available | 2023-07-27T19:49:58Z | - |
dc.date.issued | 2023-06 | - |
dc.identifier.issn | 1944-8244 | - |
dc.identifier.issn | 1944-8252 | - |
dc.identifier.uri | https://doi.org/10.1021/acsami.3c04362 | - |
dc.identifier.uri | https://hdl.handle.net/11147/13602 | - |
dc.description.abstract | Globally, one of the most common tissue transplantationproceduresis bone grafting. Lately, we have reported the development of polymerizedhigh internal phase emulsions (PolyHIPEs) made of photocurable polycaprolactone(4PCLMA) and shown their potential to be used as bone tissue engineeringscaffolds in vitro. However, it is essential to evaluatethe in vivo performance of these scaffolds to investigatetheir potential in a clinically more relevant manner. Therefore, inthis study, we aimed to compare in vivo performancesof macroporous (fabricated using stereolithography), microporous (fabricatedusing emulsion templating), and multiscale porous (fabricated usingemulsion templating and perforation) scaffolds made of 4PCLMA. Also,3D-printed macroporous scaffolds (fabricated using fused depositionmodeling) made of thermoplastic polycaprolactone were used as a control.Scaffolds were implanted into a critical-sized calvarial defect, animalswere sacrificed 4 or 8 weeks after implantation, and the new boneformation was assessed by micro-computed tomography, dental radiography,and histology. Multiscale porous scaffolds that include both micro-and macropores resulted in higher bone regeneration in the defectarea compared to only macroporous or only microporous scaffolds. Whenone-grade porous scaffolds were compared, microporous scaffolds showedbetter performance than macroporous scaffolds in terms of mineralizedbone volume and tissue regeneration. Micro-CT results revealed thatwhile bone volume/tissue volume (Bv/Tv) values were 8 and 17% at weeks4 and 8 for macroporous scaffolds, they were significantly higherfor microporous scaffolds, with values of 26 and 33%, respectively.Taken together, the results reported in this study showed the potentialapplication of multiscale PolyHIPE scaffolds, in particular, as apromising material for bone regeneration. | en_US |
dc.description.sponsorship | We acknowledge the Medical Research Council (grant no. MR/L012669/1), the Engineering and Physical Sciences Research Council (grant no. EP/I007695/1), the Department of Scientific Research Projects of Izmir Institute of Technology (IZTECH-BAP, 2021-IYTE-1-0110 and 2022-IIYTE-2-0025), Health Institutes of Turkey (TUSEB-2022B02-22517), National Science and Technology Council (MOST107-2314-B-016-020), Medical Affairs Bureau Ministry of National Defense (MAB-107-056), and Tri-Service General Hospital (TSGH-C108-031). F.C. also thanks the Royal Society for funding a Royal Society Leverhulme Trust Senior Research Fellowship 2022 (SRF\R1\221053). B.A.D. and S.D. also acknowledge IzTech Integrated Research Centers (IzTech IRC), the Center for Materials Research. | en_US |
dc.language.iso | en | en_US |
dc.publisher | American Chemical Society | en_US |
dc.relation.ispartof | ACS Applied Materials & Interfaces | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Polycaprolactone | en_US |
dc.subject | Emulsion templating | en_US |
dc.subject | 3D printing | en_US |
dc.subject | Stereolithography | en_US |
dc.subject | Bone tissue engineering | en_US |
dc.subject | Multiscale porosity | en_US |
dc.subject | Templated Scaffolds | en_US |
dc.title | In Vivo Bone Regeneration Capacity of Multiscale Porous Polycaprolactone-Based High Internal Phase Emulsion (polyhipe) Scaffolds in a Rat Calvarial Defect Model | en_US |
dc.type | Article | en_US |
dc.authorid | 0000-0002-5516-469X | - |
dc.authorid | 0000-0001-9933-5254 | - |
dc.institutionauthor | Aldemir Dikici, Betül | - |
dc.institutionauthor | Dikici, Serkan | - |
dc.department | İzmir Institute of Technology. Bioengineering | en_US |
dc.identifier.volume | 15 | en_US |
dc.identifier.issue | 23 | en_US |
dc.identifier.startpage | 27696 | en_US |
dc.identifier.endpage | 27705 | en_US |
dc.identifier.wos | WOS:001008292700001 | - |
dc.identifier.scopus | 2-s2.0-85162886355 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1021/acsami.3c04362 | - |
dc.identifier.pmid | 37253168 | - |
dc.authorscopusid | 57188877982 | - |
dc.authorscopusid | 57207989855 | - |
dc.authorscopusid | 57188879686 | - |
dc.authorscopusid | 7401986384 | - |
dc.authorscopusid | 55987061100 | - |
dc.identifier.wosquality | Q1 | - |
dc.identifier.scopusquality | Q1 | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
crisitem.author.dept | 03.01. Department of Bioengineering | - |
crisitem.author.dept | 03.01. Department of Bioengineering | - |
Appears in Collections: | Bioengineering / Biyomühendislik PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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File | Size | Format | |
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In-Vivo-Bone-Regeneration.pdf | 11.51 MB | Adobe PDF | View/Open |
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