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Title: Epitranscriptomics changes the play: m6A RNA modifications in apoptosis
Authors: Akçaöz, Azime
Akgül, Bünyamin
Keywords: Apoptosis
RNA modification
Issue Date: 2022
Publisher: Springer
Abstract: Apoptosis is a form of programmed cell death that is essential for cellular and organismal homeostasis. Any irregularities that disturb the balance between apoptosis and cell survival have severe implications, such as improper development or life-threatening diseases. Thus, it is highly critical to maintain a proper rate of apoptosis throughout development. In fact, several complex transcriptional and posttranscriptional mechanisms exist in eukaryotes to critically regulate the rate of apoptotic processes. Recent studies suggest that not only RNA sequences but also their modifications, such as m6A methylation, play a fundamental role in these transcriptional and posttranscriptional processes. A specific set of proteins, called writer, eraser, and reader of m6A marks, modulate the rate of apoptosis by determining the m6A repertoire and the fate of certain transcripts associated with apoptosis. In this Review, we will cover the dynamic m6A RNA modifications and their impact on modulation of apoptosis.
Description: The authors would like to thank BIOMER (IZTECH, Turkey) for the instrumental help during m6A miCLIP-seq analyses. This study was funded by the Scientific and Technological Research Council of Turkey (TÜBİTAK) (Project No: 217Z234 to BA).
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

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