Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/12771
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dc.contributor.authorAkarsu, Ayşegül-
dc.contributor.authorÖksel Karakuş, Ceyda-
dc.contributor.authorOcak, Melike-
dc.contributor.authorOral, Nihan-
dc.contributor.authorBilgi, Eyüp-
dc.contributor.authorŞahiner, Ümit Murat-
dc.contributor.authorSoyer, Özge-
dc.contributor.authorŞekerel, Bülent Enis-
dc.date.accessioned2023-01-18T13:32:57Z-
dc.date.available2023-01-18T13:32:57Z-
dc.date.issued2022-
dc.identifier.issn1018-2438-
dc.identifier.urihttps://doi.org/10.1159/000527534-
dc.identifier.urihttps://hdl.handle.net/11147/12771-
dc.description.abstractIntroduction: Food allergy (FA) is a heterogeneous disease with multiple morbidities and a huge burden for patients and healthcare systems. Variable manifestations, comorbidities (atopic dermatitis [AD], asthma, and/or allergic rhinitis [AR]), severity (anaphylaxis), and outcomes suggest the existence of different endotypes that cluster analyses may reveal. In this study, we aimed to investigate distinct subgroups among patients with FAs using data from 524 children/adolescents. Methods: 524 patients with IgE-mediated FA (353 male [67%]; median age 4.4 years [IQR:3.0-6.8]), 354 (68%) had multiple FA. The history of AD, asthma, AR, and anaphylaxis was recorded in 59.4%, 35.5%, 24.2%, and 51.2% of the patients, respectively. Latent class analysis was carried out to distinguish clinical FA phenotypes using five potential markers of allergy severity (single/multiple FA, never/inactive/current asthma and AD, AR, and anaphylaxis). Results: Three distinct phenotypes were identified: (1) multiple FA with eczema and respiratory multimorbidity (42%), (2) multiple FA with persistent eczema (34%), and (3) single FA with respiratory multimorbidity without eczema (24%). Compared with the single FA cluster, the prevalence of AD was significantly higher in multiple FA groups. Cluster 1 had the highest frequency of AR and allergic asthma, and the lowest rate of total tolerance of FA. Discussion: We put forward the hypothesis of underlying pathogenesis according to the clinical phenotypes. While skin barrier defect may play a dominant role in the pathogenesis in Cluster 2, immune dysregulation may be dominant in Cluster 3. In Cluster 1, the most severe group, a combination of both skin barrier defects and immune dysregulation may be responsible for the clinical features.en_US
dc.language.isoenen_US
dc.publisherS. Karger AGen_US
dc.relationSafer-by-Design Strategies for Bio-Nanomaterials (SAFEbionano)en_US
dc.relation.ispartofInternational Archives of Allergy and Immunologyen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectFood allergyen_US
dc.subjectImmune dysregulationen_US
dc.subjectPathogenesisen_US
dc.titleExploring the Heterogeneity of Ige-Mediated Food Allergy Through Latent Class Analysisen_US
dc.typeArticleen_US
dc.authorid0000-0001-5282-4114-
dc.authorid0000-0001-9644-0403-
dc.institutionauthorÖksel Karakuş, Ceyda-
dc.institutionauthorBilgi, Eyüp-
dc.departmentİzmir Institute of Technology. Bioengineeringen_US
dc.identifier.wosWOS:000894206800001-
dc.identifier.scopus2-s2.0-85144250727-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1159/000527534-
dc.identifier.pmid36470226-
dc.relation.issn1018-2438en_US
dc.relation.grantno118C229en_US
dc.identifier.wosqualityQ3-
dc.identifier.scopusqualityQ3-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
item.openairetypeArticle-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
crisitem.author.dept03.01. Department of Bioengineering-
crisitem.author.dept03.01. Department of Bioengineering-
Appears in Collections:Bioengineering / Biyomühendislik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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