Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/12490
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dc.contributor.authorÜner, Göklemen_US
dc.contributor.authorBedir, Erdalen_US
dc.contributor.authorSerçinoğlu, Onuren_US
dc.contributor.authorBallar Kırmızıbayrak, Peteken_US
dc.date.accessioned2022-09-29T10:56:22Z-
dc.date.available2022-09-29T10:56:22Z-
dc.date.issued2022-12-
dc.identifier.urihttps://doi.org/10.1038/s41598-022-17977-4-
dc.identifier.urihttps://hdl.handle.net/11147/12490-
dc.description.abstractThe discovery of novel chemotherapeutics that act through different mechanisms is critical for dealing with tumor heterogeneity and therapeutic resistance. We previously reported a saponin analog (AG-08) that induces non-canonical necrotic cell death and is auspicious for cancer therapy. Here, we describe that the key element in triggering this unique cell death mechanism of AG-08 is its ability to form supramolecular particles. These self-assembled particles are internalized via a different endocytosis pathway than those previously described. Microarray analysis suggested that AG-08 supramolecular structures affect several cell signaling pathways, including unfolded protein response, immune response, and oxidative stress. Finally, through investigation of its 18 analogs, we further determined the structural features required for the formation of particulate structures and the stimulation of the unprecedented cell death mechanism of AG-08. The unique results of AG-08 indicated that supramolecular assemblies of small molecules are promising for the field of anticancer drug development, although they have widely been accepted as nuisance in drug discovery studies.en_US
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.relationAG-07 Molekülünün Nekrotik Hücre Ölümü Üzerine Olan Etkilerinin Araştırılması-
dc.relation.ispartofScientific Reportsen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCell deathen_US
dc.subjectSupramolecular particlesen_US
dc.subjectAnticancer drug researchen_US
dc.subjectSapogeninsen_US
dc.titleNon-apoptotic cell death induction via sapogenin based supramolecular particlesen_US
dc.typeArticleen_US
dc.authorid0000-0003-4970-4837en_US
dc.authorid0000-0003-1262-063Xen_US
dc.institutionauthorÜner, Göklemen_US
dc.institutionauthorBedir, Erdalen_US
dc.departmentİzmir Institute of Technology. Bioengineeringen_US
dc.identifier.wosWOS:000841397200037en_US
dc.identifier.scopus2-s2.0-85136015306en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1038/s41598-022-17977-4-
dc.identifier.pmid35974087-
dc.relation.issn2045-2322en_US
dc.description.volume12en_US
dc.description.issue1en_US
dc.relation.grantno2017IYTE71-
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
crisitem.author.dept01. Izmir Institute of Technology-
crisitem.author.dept03.01. Department of Bioengineering-
Appears in Collections:Bioengineering / Biyomühendislik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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