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https://hdl.handle.net/11147/12363
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DC Field | Value | Language |
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dc.contributor.author | Doğan, Elvan | - |
dc.contributor.author | Kısım, Aslı | - |
dc.contributor.author | Batı Ayaz, Gizem | - |
dc.contributor.author | Kubicek, Gregory J. | - |
dc.contributor.author | Pesen Okvur, Devrim | - |
dc.contributor.author | Miri, Amir K. | - |
dc.date.accessioned | 2022-08-15T18:24:30Z | - |
dc.date.available | 2022-08-15T18:24:30Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 2699-9307 | - |
dc.identifier.uri | https://doi.org/10.1002/anbr.202100017 | - |
dc.identifier.uri | https://hdl.handle.net/11147/12363 | - |
dc.description.abstract | Microfluidic tumors-on-chips models have revolutionized anticancer therapeutic research by creating an ideal microenvironment for cancer cells. The tumor microenvironment (TME) includes various cell types and cancer stem cells (CSCs), which are postulated to regulate the growth, invasion, and migratory behavior of tumor cells. In this review, the biological niches of the TME and cancer cell behavior focusing on the behavior of CSCs are summarized. Conventional cancer models such as 3D cultures and organoid models are reviewed. Opportunities for the incorporation of CSCs with tumors-on-chips are then discussed for creating tumor invasion models. Such models will represent a paradigm shift in the cancer community by allowing oncologists and clinicians to predict better which cancer patients will benefit from chemotherapy treatments. | en_US |
dc.description.sponsorship | E.D., A.K., and G.B.-A. contributed equally to this work. A.K.M. acknowledges the receipt of R21 -DC18818 from the National Institutes of Health, Camden Health Initiative, and Seed Funding from Rowan University. D.P.-O. acknowledges the receipt of 1001-119Z109 from The Technological and Scientific Research Council of Turkey. G.B.-A. acknowledges the receipt of Ph.D. Fellowship from the YOK 100/2000 program. The authors thank all lab members for their valuable feedback and comments on this manuscript. A.K.M. acknowledges Dr. Larry Honaker (Wageningen University, The Netherlands) for his valuable comments and suggestions on the writing. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley | en_US |
dc.relation.ispartof | Advanced NanoBiomed Research | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Cancer stem cells | en_US |
dc.subject | Tumors-on-chips | en_US |
dc.subject | Tumor microenvironments | en_US |
dc.title | Cancer stem cells in tumor modeling: Challenges and future directions | en_US |
dc.type | Article | en_US |
dc.authorid | 0000-0003-1561-2547 | - |
dc.authorid | 0000-0001-8333-4193 | - |
dc.department | İzmir Institute of Technology. Molecular Biology and Genetics | en_US |
dc.identifier.volume | 1 | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.wos | WOS:000782100200002 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1002/anbr.202100017 | - |
dc.identifier.pmid | 34927168 | en_US |
dc.identifier.scopusquality | Q3 | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.openairetype | Article | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 04.03. Department of Molecular Biology and Genetics | - |
Appears in Collections: | Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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File | Size | Format | |
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Advanced NanoBiomed Research.pdf | 2.56 MB | Adobe PDF | View/Open |
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