Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/11474
Title: Benzodiazepine derivatives from marine-derived Streptomyces cacaoi 14cm034
Authors: Çetinel Aksoy, Semiha
Küçüksolak, Melis
Uzel, Ataç
Bedir, Erdal
Keywords: Marine actinobacterium
Streptomyces cacaoi
Benzodiazepine
Antimicrobial activity
Antibiotics
Issue Date: 2021
Publisher: ACG Publications
Abstract: 7-methoxy-8-hydroxy cycloanthranilylproline (2), a new natural product with pyrrolobenzodiazepine (PBD) framework, was isolated from marine-derived actinobacterium Streptomyces cacaoi 14CM034, together with cycloanthranilylproline (1). Structural elucidation of the compounds was based on FTIR, 1D-(H-1 and C-13 NMR), 2D-NMR (COSY, HMBC and NOESY) and HR-MS analyses. Compounds 1 and 2 exhibited notable antimicrobial activity. The presence of PBD derivatives in S. cacaoi was first demonstrated with this study.
URI: https://doi.org/10.25135/rnp.203.20.08.1766
https://hdl.handle.net/11147/11474
ISSN: 1307-6167
Appears in Collections:Bioengineering / Biyomühendislik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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