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Title: Multi-organs-on-chips for testing small-molecule drugs: Challenges and perspectives
Authors: Çeçen, Berivan
Karavasili, Christina
Nazir, Mubashir
Bhusal, Anant
Doğan, Elvan
Shahriyari, Fatemeh
Tamburacı, Sedef
Miri, Amir K.
Keywords: High-throughput screening
Small drugs
Issue Date: 2021
Publisher: MDPI
Abstract: Organ-on-a-chip technology has been used in testing small-molecule drugs for screening potential therapeutics and regulatory protocols. The technology is expected to boost the development of novel therapies and accelerate the discovery of drug combinations in the coming years. This has led to the development of multi-organ-on-a-chip (MOC) for recapitulating various organs involved in the drug–body interactions. In this review, we discuss the current MOCs used in screening small-molecule drugs and then focus on the dynamic process of drug absorption, distribution, metabolism, and excretion. We also address appropriate materials used for MOCs at low cost and scale-up capacity suitable for high-performance analysis of drugs and commercial high-throughput screening platforms. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
ISSN: 1999-4923
Appears in Collections:Chemical Engineering / Kimya Mühendisliği
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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