Please use this identifier to cite or link to this item:
Title: The role of miRNA in cancer: Pathogenesis, diagnosis, and treatment
Authors: Uzuner, Erez
Ulu, Gizem Tuğçe
Gürler, Sevim Beyza
Baran, Yusuf
Keywords: miRNA
miRNA-based cancer treatment
miRNAs in apoptosis
miRNAs in growth
miRNAs in proliferation
Oncogenic miRNA
Tumor suppressor miRNA
Issue Date: 2022
Publisher: Humana Press
Abstract: Cancer is also determined by the alterations of oncogenes and tumor suppressor genes. These gene expressions can be regulated by microRNAs (miRNA). At this point, researchers focus on addressing two main questions: “How are oncogenes and/or tumor suppressor genes regulated by miRNAs?” and “Which other mechanisms in cancer cells are regulated by miRNAs?” In this work we focus on gathering the publications answering these questions. The expression of miRNAs is affected by amplification, deletion or mutation. These processes are controlled by oncogenes and tumor suppressor genes, which regulate different mechanisms of cancer initiation and progression including cell proliferation, cell growth, apoptosis, DNA repair, invasion, angiogenesis, metastasis, drug resistance, metabolic regulation, and immune response regulation in cancer cells. In addition, profiling of miRNA is an important step in developing a new therapeutic approach for cancer. © 2022, Springer Science+Business Media, LLC, part of Springer Nature.
ISSN: 1064-3745
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Show full item record

CORE Recommender


checked on Jun 3, 2023

Page view(s)

checked on May 22, 2023

Google ScholarTM



Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.