Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/11243
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dc.contributor.authorAkgül, B.-
dc.contributor.authorStadler, P.F.-
dc.contributor.authorHawkins, L.J.-
dc.contributor.authorHadj-Moussa, H.-
dc.contributor.authorStorey, K.B.-
dc.contributor.authorErgin, K.-
dc.contributor.authorAllmer, J.-
dc.date.accessioned2021-11-06T09:23:36Z-
dc.date.available2021-11-06T09:23:36Z-
dc.date.issued2022-
dc.identifier.issn1064-3745-
dc.identifier.urihttp://doi.org/10.1007/978-1-0716-1170-8_19-
dc.identifier.urihttps://hdl.handle.net/11147/11243-
dc.description.abstractMature microRNAs (miRNAs) are short RNA sequences about 18–24 nucleotide long, which provide the recognition key within RISC for the posttranscriptional regulation of target RNAs. Considering the canonical pathway, mature miRNAs are produced via a multistep process. Their transcription (pri-miRNAs) and first processing step via the microprocessor complex (pre-miRNAs) occur in the nucleus. Then they are exported into the cytosol, processed again by Dicer (dsRNA) and finally a single strand (mature miRNA) is incorporated into RISC (miRISC). The sequence of the incorporated miRNA provides the function of RNA target recognition via hybridization. Following binding of the target, the mRNA is either degraded or translation is inhibited, which ultimately leads to less protein production. Conversely, it has been shown that binding within the 5? UTR of the mRNA can lead to an increase in protein product. Regulation of homeostasis is very important for a cell; therefore, all steps in the miRNA-based regulation pathway, from transcription to the incorporation of the mature miRNA into RISC, are under tight control. While much research effort has been exerted in this area, the knowledgebase is not sufficient for accurately modelling miRNA regulation computationally. The computational prediction of miRNAs is, however, necessary because it is not feasible to investigate all possible pairs of a miRNA and its target, let alone miRNAs and their targets. We here point out open challenges important for computational modelling or for our general understanding of miRNA-based regulation and show how their investigation is beneficial. It is our hope that this collection of challenges will lead to their resolution in the near future. © 2022, Springer Science+Business Media, LLC, part of Springer Nature.en_US
dc.language.isoenen_US
dc.publisherHumana Press Inc.en_US
dc.relation.ispartofMethods in Molecular Biologyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChallengesen_US
dc.subjectMature miRNAen_US
dc.subjectmiRNA predictionen_US
dc.subjectmiRNA targetingen_US
dc.subjectmiRNomicsen_US
dc.subjectRISCen_US
dc.title44 Current Challenges in miRNomicsen_US
dc.typeBook Parten_US
dc.departmentİYTEen_US
dc.identifier.volume2257en_US
dc.identifier.startpage423en_US
dc.identifier.endpage438en_US
dc.identifier.scopus2-s2.0-85114096543en_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.identifier.doi10.1007/978-1-0716-1170-8_19-
dc.identifier.pmid34432289en_US
dc.authorscopusid6602666808-
dc.authorscopusid7102702401-
dc.authorscopusid57194539112-
dc.authorscopusid56346628600-
dc.authorscopusid57242707800-
dc.authorscopusid22134235200-
dc.authorscopusid57242961700-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairetypeBook Part-
item.languageiso639-1en-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
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