Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/11140
Title: Cytotoxic and apoptotic effects of 1,2-diborolanes with strong donor substitutes on human cancer cells
Authors: Şahin, Yüksel
Aslantürk, Özlem Sultan
Çelik, Tülay
Sevinçek, Resul
Aygün, Muhittin
Metin, Kubilay
Fırıncı, Erkan
Özgener, Hüseyin
Adnan Menderes Üniversitesi
Adnan Menderes Üniversitesi
Adnan Menderes Üniversitesi
Dokuz Eylül Üniversitesi
Dokuz Eylül Üniversitesi
Adnan Menderes Üniversitesi
Adnan Menderes Üniversitesi
Izmir Institute of Technology
Keywords: Cytotoxic effects
Cancer
Diborolane
Mitochondrial membrane potential
Issue Date: Oct-2021
Publisher: Elsevier
Abstract: In recent years, boron compounds have become more common as chemotherapy agents against certain types of cancers. Along with the development of boron-based therapeutic agents have come investigations into the various cancers and biochemical and molecular mechanisms affected by boron compounds and the relationships between boron compounds and chemical protection against cancer. In this preliminary study, the effects of new 1,2-N-substituted-1,2-diborolane derivatives on types of breast and liver cancers were examined for the first time. Four were found to significantly affect the cell viabilities and mitochondrial membrane potential changes in MCF-7, HepG2 and Hep3B cancer cells. Each was prepared in n-hexane at various concentrations (5, 10, 25, 50, 75 and 100 µg/mL). Human peripheral blood lymphocytes were used as control cells. Compounds 1, 2, 3a, and 3b 1,2-diborolane derivatives selectively killed cancer cells, but compound 1 was cytotoxic in a concentration-dependent manner on HepG2 and Hep3B and only at concentrations of at least 75 µg/mL on MCF-7 cells. Compound 3a exhibited cytotoxic effect on lymphocytes at 75 and 100 µgmL-1 concentrations, but compounds 1, 2 and 3b, 3c and 3d have not possessed significant cytotoxic effect on lymphocytes. Compounds 3c and 3d have not possessed significant cytotoxic effects. Mitochondrial membrane potential assay results supported these findings. Our results reveal that 1,2-diborolane derivates have high cytotoxic and apoptotic activities on human hepatocarcinoma cells and are therefore potential candidates in the development of new drugs against liver cancer.
URI: https://hdl.handle.net/11147/11140
https://doi.org/10.1016/j.bioorg.2021.105443
Appears in Collections:Chemistry / Kimya
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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