Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/10409
Title: Nuclear-targeted gold nanoparticles enhance cancer cell radiosensitization
Authors: Özçelik, Serdar
Pratx, Guillem
Keywords: Gold nanoparticles
nuclear targeting
NLS peptide modification
Radiosensitization
Publisher: IOP Publishing
Abstract: Radiation therapy aims to kill or inhibit proliferation of cancer cells while sparing normal cells. To enhance radiosensitization, we developed 40 nm-sized gold nanoparticles targeting the nucleus. We exploited a strategy that combined RGD and NLS peptides respectively targeting cancer cell and the nucleus to initiate cell-death activated by x-ray irradiation. We observed that the modified gold nanoparticles were either translocated in the nuclei or accumulated in the vicinity of the nuclei. We demonstrated that x-ray irradiation at 225 kVp energy reduced cell proliferation by 3.8-fold when the nuclear targeted gold nanoparticles were used. We determined that the radiation dose to have a 10% survival fraction was reduced from 11.0 Gy to 7.1 Gy when 10.0 mu g ml(-1)of the NLS/RGD/PEG-AuNP was incubated with A549 cancer cells. We conclude that the peptide-modified gold nanoparticles targeting the nucleus significantly enhance radiosensitization.
URI: https://doi.org/10.1088/1361-6528/aba02b
https://hdl.handle.net/10409
ISSN: 0957-4484
1361-6528
Appears in Collections:Chemistry / Kimya
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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