Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/9381
Title: A new semi-synthetic sapogenol derivative inducing regulated necrosis
Authors: Üner, Göklem
Ballar Kırmızıbayrak, Petek
Bedir, Erdal
Issue Date: 2019
Publisher: Georg Thieme Verlag
Abstract: Since saponin’s antitumor potency is relatively weak, researchers focus on their semi-synthetic modification to obtain structures with higher potencies. With the same motivation, we prepared a cytotoxic sapogenol derivative (AG-08) from cycloastragenol. Our preliminary studies revealed that AG-08 induced primarily necrotic cell death along with autophagic inhibition. Furthermore, immunoblotting experiments demonstrated that AG-08 promoted cleavage of various proteins such as ATGs, p62, and PARP-1.
Description: 67th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) -- SEP 01-05, 2019 -- Innsbruck, AUSTRIA
URI: https://doi.org/10.1055/s-0039-3399943
https://hdl.handle.net/11147/9381
ISSN: 0032-0943
1439-0221
Appears in Collections:Bioengineering / Biyomühendislik
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Show full item record

CORE Recommender

Page view(s)

84
checked on Jan 23, 2023

Google ScholarTM

Check

Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.