Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/9381
Full metadata record
DC FieldValueLanguage
dc.contributor.authorÜner, Göklem-
dc.contributor.authorBallar Kırmızıbayrak, Petek-
dc.contributor.authorBedir, Erdal-
dc.date.accessioned2020-07-25T22:10:43Z-
dc.date.available2020-07-25T22:10:43Z-
dc.date.issued2019-
dc.identifier.issn0032-0943-
dc.identifier.issn1439-0221-
dc.identifier.urihttps://doi.org/10.1055/s-0039-3399943-
dc.identifier.urihttps://hdl.handle.net/11147/9381-
dc.description67th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) -- SEP 01-05, 2019 -- Innsbruck, AUSTRIAen_US
dc.description.abstractSince saponin’s antitumor potency is relatively weak, researchers focus on their semi-synthetic modification to obtain structures with higher potencies. With the same motivation, we prepared a cytotoxic sapogenol derivative (AG-08) from cycloastragenol. Our preliminary studies revealed that AG-08 induced primarily necrotic cell death along with autophagic inhibition. Furthermore, immunoblotting experiments demonstrated that AG-08 promoted cleavage of various proteins such as ATGs, p62, and PARP-1.en_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlagen_US
dc.relation.ispartofPlanta Medicaen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleA new semi-synthetic sapogenol derivative inducing regulated necrosisen_US
dc.typeConference Objecten_US
dc.institutionauthorÜner, Göklem-
dc.institutionauthorBedir, Erdal-
dc.departmentİzmir Institute of Technology. Bioengineeringen_US
dc.identifier.volume85en_US
dc.identifier.issue18en_US
dc.identifier.startpage1507en_US
dc.identifier.endpage1507en_US
dc.identifier.wosWOS:000503772900316en_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1055/s-0039-3399943-
dc.relation.doi10.1055/s-0039-3399943en_US
dc.coverage.doi10.1055/s-0039-3399943en_US
dc.identifier.wosqualityQ2-
dc.identifier.scopusqualityQ3-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.openairetypeConference Object-
item.languageiso639-1en-
crisitem.author.dept01. Izmir Institute of Technology-
crisitem.author.dept03.01. Department of Bioengineering-
Appears in Collections:Bioengineering / Biyomühendislik
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Show simple item record



CORE Recommender

Page view(s)

220
checked on Nov 25, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.