Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/9074
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dc.contributor.authorGüdücü, Çağdaş-
dc.contributor.authorOlcay, Bilal Orkan-
dc.contributor.authorSchaefer, L.-
dc.contributor.authorAziz, M.-
dc.contributor.authorSchriever, V. A.-
dc.contributor.authorÖzgören, Murat-
dc.contributor.authorHummel, T.-
dc.date.accessioned2020-07-25T22:03:28Z-
dc.date.available2020-07-25T22:03:28Z-
dc.date.issued2019-
dc.identifier.issn0006-8993-
dc.identifier.issn1872-6240-
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2018.12.012-
dc.identifier.urihttps://hdl.handle.net/11147/9074-
dc.descriptionPubMed: 30537519en_US
dc.description.abstractObjective: Methods based on electroencephalography (EEG) are used to evaluate brain responses to odors which is challenging due to the relatively low signal-to-noise ratio. This is especially difficult in patients with olfactory loss. In the present study, we aim to establish a method to separate functionally anosmic and normosmic individuals by means of recordings of olfactory event-related potentials (OERP) using an automated tool. Therefore, Shannon entropy was adopted to examine the complexity of the averaged electrophysiological responses. Methods: A total of 102 participants received 60 rose-like odorous stimuli at an inter-stimulus interval of 10 s. Olfactory-related brain activity was investigated within three time-windows of equal length; pre-, during-, and post-stimulus. Results: Based on entropy analysis, patients were correctly diagnosed for anosmia with a 75% success rate. Conclusion: This novel approach can be expected to help clinicians to identify patients with anosmia or patients with early symptoms of neurodegenerative disorders. Significance: There is no automated diagnostic tool for anosmic and normosmic patients using OERP. However, detectability of OERP in patients with functional anosmia has been reported to be in the range of 50%.en_US
dc.language.isoenen_US
dc.publisherElsevier Ltd.en_US
dc.relation.ispartofBrain Researchen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOlfactionen_US
dc.subjectEEGen_US
dc.subjectAnosmiaen_US
dc.subjectDiagnosisen_US
dc.subjectShannon Entropyen_US
dc.subjectKozachenko-Leonenko entropy estimationen_US
dc.titleSeparating normosmic and anosmic patients based on entropy evaluation of olfactory event-related potentialsen_US
dc.typeArticleen_US
dc.authorid0000-0003-3721-6756-
dc.institutionauthorOlcay, Bilal Orkan-
dc.departmentIzmir Institute of Technology. Electronics and Communication Engineeringen_US
dc.identifier.volume1708en_US
dc.identifier.startpage78en_US
dc.identifier.endpage83en_US
dc.identifier.wosWOS:000460712300009en_US
dc.identifier.scopus2-s2.0-85058439937en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.brainres.2018.12.012-
dc.identifier.pmid30537519en_US
dc.relation.doi10.1016/j.brainres.2018.12.012en_US
dc.coverage.doi10.1016/j.brainres.2018.12.012en_US
dc.identifier.scopusqualityQ2-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.grantfulltextembargo_20230101-
item.openairetypeArticle-
item.languageiso639-1en-
Appears in Collections:Electrical - Electronic Engineering / Elektrik - Elektronik Mühendisliği
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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