Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/7914
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dc.contributor.authorMeşe, Gülistan-
dc.contributor.authorYalçın Özuysal, Özden-
dc.date.accessioned2020-07-18T03:35:22Z-
dc.date.available2020-07-18T03:35:22Z-
dc.date.issued2016-
dc.identifier.isbn9783319249513; 9783319249490-
dc.identifier.urihttps://doi.org/10.1007/978-3-319-24951-3_9-
dc.identifier.urihttps://hdl.handle.net/11147/7914-
dc.description.abstractBreast cancer, a heterogeneous disease comprised of tumors with different histological characteristics and clinical outcomes, is the leading cause of cancer deaths in women. Heterogeneous nature of the breast cancer demands delicate approaches to diagnose and follow the most appropriate strategy for clinical management. Based on microarray analysis of mRNA expression, four main molecular subtypes were identified: (a) luminal A, (b) luminal B, (c) basal-like, and (d) ERBB2(+). Even though molecular subtypes provided novel insights into our understanding of breast cancer heterogeneity, there is still room for improvement for better diagnostic, prognostic and therapeutic approaches. In this sense, epigenetics, specifically DNA methylation and histone modifications, have emerged as prominent candidates since several epigenetic factors were observed to be recurrently mutated in cancers including breast cancer. Recent advances in the field implicated that DNA methylation profiles and histone modifications are strongly associated with breast tumor subtypes and patient prognosis. Therefore, understanding contributions of epigenetics to breast cancer biology will lead to better diagnostic and prognostic strategies and will enable development of novel therapeutic approaches. © Springer International Publishing Switzerland 2016.en_US
dc.language.isoenen_US
dc.publisherSpringer Verlagen_US
dc.relation.ispartofEpigenetic Advancements in Canceren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast canceren_US
dc.subjectDNA methylationen_US
dc.subjectEpigeneticen_US
dc.subjectGlobal alterationsen_US
dc.subjectHistone modificationsen_US
dc.subjectMethylomeen_US
dc.subjectMolecular subtypesen_US
dc.titleEpigenetics of breast cancer: DNA methylome and global histone modificationsen_US
dc.typeBook Parten_US
dc.institutionauthorMeşe, Gülistan-
dc.institutionauthorYalçın Özuysal, Özden-
dc.departmentIzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.startpage207en_US
dc.identifier.endpage228en_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.identifier.doi10.1007/978-3-319-24951-3_9-
dc.relation.doi10.1007/978-3-319-24951-3_9en_US
dc.coverage.doi10.1007/978-3-319-24951-3_9en_US
item.openairetypeBook Part-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.cerifentitytypePublications-
crisitem.author.deptDepartment of Molecular Biology and Genetics-
crisitem.author.deptDepartment of Molecular Biology and Genetics-
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
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