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Title: Hierarchically porous polymer derived ceramics: A promising platform for multidrug delivery systems
Authors: Vakıfahmetoğlu, Çekdar
Zeydanlı, Damla
Özalp, Veli Cengiz
Borsa, Barış Ata
Soraru, Gian Domenico
Keywords: Hierarchical porous ceramics
High surface area
Multidrug deliveries
Drug delivery systems
Silicon compounds
Publisher: Elsevier Ltd.
Source: Ahmetoğlu, Ç. V., Zeydanlı, D., Özalp, V. C., Borsa, B. A., Soraru, G. D. (2018). Hierarchically porous polymer derived ceramics: A promising platform for multidrug delivery systems. Materials and Design, 140, 37-44. doi:10.1016/j.matdes.2017.11.047
Abstract: Mesoporous silicon oxycarbide (SiOC) components were formed with the use of “molecular spacer” (a sacrificial vinyl-terminated linear siloxane which while decomposing during pyrolysis generates pores with size proportional to the molecular weight), followed by a post-pyrolysis etching treatment by hydrofluoric acid (HF) to obtain C-rich SiOC samples having additional micro-/mesoporosity and specific surface area reaching to 774 m2/g. The biocompatibility of the samples was validated by hemolysis test, and their cargo/drug loading capacities were studied by two different sized polypeptides as model molecules. SiOC particles showed less hemolysis compared to the reference material MCM-41. Similarly, the loading capacity and the release kinetics of bovine serum albumin (BSA) and vancomycin-loaded SiOC particles were improved compared to that of MCM-41. In the multi cargo loading/release capacity tests, done by using different sized molecules, Bio2-HF and MCM-41 were loaded both with fluorescein and BSA. While a lagging time in fluorescein release was observed for MCM-41, the release kinetics of fluorescein and BSA was not affected when they are loaded together in the hierarchical pores of Bio2-HF, allowing the release of both large and small cargo molecules. The antimicrobial activity tests showed that Bio2-HF performed better than MCM-41 particles in improving bactericidal activity.
ISSN: 0264-1275
Appears in Collections:Materials Science and Engineering / Malzeme Bilimi ve Mühendisliği
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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