Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/7069
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dc.contributor.authorŞentürk, Nesligül-
dc.contributor.authorTop, Ayben-
dc.date.accessioned2018-12-25T08:57:32Z-
dc.date.available2018-12-25T08:57:32Z-
dc.date.issued2018-
dc.identifier.citationŞentürk, N., and Top, A. (2018). PEG-peptide conjugate containing cathepsin B degradation unit as a doxorubicin carrier system. Turkish Journal of Chemistry, 42(2), 385-400. doi:10.3906/kim-1706-65en_US
dc.identifier.issn1300-0527-
dc.identifier.issn1303-6130-
dc.identifier.urihttp://doi.org/10.3906/kim-1706-65-
dc.identifier.urihttp://hdl.handle.net/11147/7069-
dc.description.abstractA drug delivery system (DDS) containing a cathepsin B degradable sequence and pH-responsive histidines was prepared by methoxypolyethylene glycol and peptide conjugation. Doxorubicin was attached to the carrier system using amide linkage to give the final form of the DDS, denoted as mPEG-AT3-DOX. mPEG-AT3-DOX exhibited a bimodal size distribution at about 15 and 30 nm independent of pH, whereas the size of the control DDS containing no peptide sequence, mPEG-DOX, was measured as ∼ 15–20 nm. At the end of 72 h, % doxorubicin release from both of the DDSs was observed to be below 8.5 ± 3% in the absence of cathepsin B, and it increased to 17 ± 2% in the presence of cathepsin B for mPEG-AT3-DOX. Complete degradation of AT3 peptide within 3 h upon incubation with cathepsin B suggests that lower than expected doxorubicin release is likely due to the aggregation tendency of mPEG-AT3-DOX. Absolute IC50 values indicated that the cytotoxicity trend of the samples is in the order of free DOX ≥ mPEG-AT3-DOX >mPEG-DOX. Considering these results, PEG-peptide-doxorubicin conjugates can be promising candidates in cancer therapy if they are designed to have more pronounced pH-responsive behavior to increase the drug release rate.en_US
dc.description.sponsorshipthe Scienti c and Technological Research Council of Turkey with grant number 112S554en_US
dc.language.isoengen_US
dc.publisherTUBITAKen_US
dc.relationinfo:eu-repo/grantAgreement/TUBITAK/SBAG/112S554en_US
dc.relation.ispartofTurkish Journal of Chemistryen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCathepsin Ben_US
dc.subjectControlled releaseen_US
dc.subjectDoxorubicinen_US
dc.subjectPolymer conjugatesen_US
dc.titlePEG-peptide conjugate containing cathepsin B degradation unit as a doxorubicin carrier systemen_US
dc.typearticleen_US
dc.authoridTR114274en_US
dc.contributor.institutionauthorŞentürk, Nesligül-
dc.contributor.institutionauthorTop, Ayben-
dc.contributor.departmentIzmir Institute of Technology. Chemical Engineeringen_US
dc.identifier.volume42en_US
dc.identifier.issue2en_US
dc.identifier.startpage385en_US
dc.identifier.endpage400en_US
dc.identifier.wosWOS:000431245300015
dc.identifier.scopusSCOPUS:2-s2.0-85047995759
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.3906/kim-1706-65-
dc.relation.doi10.3906/kim-1706-65en_US
dc.coverage.doi10.3906/kim-1706-65en_US
item.openairetypearticle-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
crisitem.author.deptDepartment of Chemical Engineering-
Appears in Collections:Chemical Engineering / Kimya Mühendisliği
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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